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CLEC4D

GENERAL INFORMATION

Gene name

 CLEC4D

Gene description

 C-type lectin domain family 4, member D

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (appendix, bone marrow)
GTEx:Group enriched (lung, spleen)
FANTOM5:Tissue enhanced (lymph node, spleen)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA004906
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (appendix, bone marrow)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lung, spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, spleen)

GENE INFORMATION

Gene name

 CLEC4D (HGNC Symbol)

Synonyms

 CD368, CLECSF8, Mpcl

Description

 C-type lectin domain family 4, member D (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 8509475 - 8522366

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166527 (version 83.38)

Entrez gene

 338339

UniProt

 Q8WXI8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WXI8

Antibodypedia

 CLEC4D antibodies

PROTEIN BROWSER
CLEC4D-001
CLEC4D-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLEC4D-001
ENSP00000299665
ENST00000299665
Q8WXI8 [Direct mapping]
C-type lectin domain family 4 member D
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
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GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002292 [T cell differentiation involved in immune response]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0030246 [carbohydrate binding]
GO:0034987 [immunoglobulin receptor binding]
GO:0038094 [Fc-gamma receptor signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0045087 [innate immune response]
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 215 aa
24.7 kDa 		No 1
CLEC4D-002
ENSP00000371496
ENST00000382064
A6NHA5 [Direct mapping]
C-type lectin domain family 4 member D
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
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GO:0016021 [integral component of membrane]
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 144 aa
16.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.