Tissue expression of SLC38A8 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLC38A8
Gene description	Solute carrier family 38, member 8
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Not detected
GTEx:	Tissue enhanced (cerebral cortex, hypothalamus, pituitary gland)
FANTOM5:	Not detected

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Not detected
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, hypothalamus, pituitary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Not detected

GENE INFORMATION
Gene name	SLC38A8
Synonyms
Description	Solute carrier family 38, member 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a putative sodium-dependent amino-acid/proton antiporter. The protein has eleven transmembrane domains, an extracellular N-terminus and an intracellular C-terminal tail. The protein is a member of the SLC38 sodium-coupled neutral amino acid transporter family of proteins. Mutations in this gene result in foveal hypoplasia with or without optic nerve misrouting and/or anterior segment dysgenesis. [provided by RefSeq, May 2014]
Chromosome	16
Cytoband	q23.3
Chromosome location (bp)	84009667 - 84042636
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166558 (version 83.38)
Entrez gene	146167
UniProt	A6NNN8 (UniProt - Evidence at protein level)
neXtProt	NX_A6NNN8
Antibodypedia	SLC38A8 antibodies

PROTEIN BROWSER

SLC38A8-001	SLC38A8-002	SLC38A8-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC38A8-001 ENSP00000299709 ENST00000299709	A6NNN8 [Direct mapping] Putative sodium-coupled neutral amino acid transporter 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0003333 [amino acid transmembrane transport] GO:0006814 [sodium ion transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0016021 [integral component of membrane] Show all	435 aa 46.7 kDa	No	>9
SLC38A8-002 ENSP00000457737 ENST00000568178	H3BUP5 [Direct mapping] Putative sodium-coupled neutral amino acid transporter 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0003333 [amino acid transmembrane transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0016021 [integral component of membrane] Show all	262 aa 27.9 kDa	No	6
SLC38A8-003 ENSP00000455085 ENST00000569816	H3BP02 [Direct mapping] Putative sodium-coupled neutral amino acid transporter 8 Show all	Predicted intracellular proteins Show all	GO:0003333 [amino acid transmembrane transport] GO:0015171 [amino acid transmembrane transporter activity] Show all	46 aa 5.1 kDa	No	0