Expression of MMP10 in cancer - Summary - The Human Protein Atlas

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MMP10

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MMP10
Gene description	Matrix metallopeptidase 10
Protein class	Cancer-related genes Enzymes FDA approved drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Cell line enhanced (BJ, HUVEC TERT2, SCLC-21H)
HPA (normal tissue):	Tissue enriched (endometrium)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. CAB002159
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB002159

GENE INFORMATION
Gene name	MMP10 (HGNC Symbol)
Synonyms	STMY2
Description	Matrix metallopeptidase 10 (HGNC Symbol)
Entrez gene summary	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q22.2
Chromosome location (bp)	102770503 - 102780628
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166670 (version 83.38)
Entrez gene	4319
UniProt	P09238 (UniProt - Evidence at protein level)
neXtProt	NX_P09238
Antibodypedia	MMP10 antibodies

PROTEIN BROWSER

MMP10-001	MMP10-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MMP10-001 ENSP00000279441 ENST00000279441	P09238 [Direct mapping] Stromelysin-2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030334 [regulation of cell migration] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] Show all	476 aa 54.2 kDa	Yes	0
MMP10-002 ENSP00000441485 ENST00000539681	F5GYX7 [Direct mapping] Stromelysin-2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] Show all	181 aa 20.5 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.