Expression of NNMT in cancer - Summary - The Human Protein Atlas

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NNMT

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NNMT
Gene description	Nicotinamide N-methyltransferase
Protein class	Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (LHCN-M2, RPTEC TERT1, SiHa)
HPA (normal tissue):	Tissue enhanced (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a few tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA059180
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), stomach cancer (unfavourable) and head and neck cancer (unfavourable).
Renal cancer p<0.001 Stomach cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA059180

GENE INFORMATION
Gene name	NNMT
Synonyms
Description	Nicotinamide N-methyltransferase (HGNC Symbol)
Entrez gene summary	N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q23.2
Chromosome location (bp)	114257787 - 114313285
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166741 (version 83.38)
Entrez gene	4837
UniProt	P40261 (UniProt - Evidence at protein level)
neXtProt	NX_P40261
Antibodypedia	NNMT antibodies

PROTEIN BROWSER

NNMT-001	NNMT-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NNMT-001 ENSP00000441434 ENST00000535401	P40261 [Direct mapping] Nicotinamide N-methyltransferase Q6FH49 [Target identity:100%; Query identity:100%] NNMT protein; Nicotinamide N-methyltransferase; Nicotinamide N-methyltransferase, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0006805 [xenobiotic metabolic process] GO:0008112 [nicotinamide N-methyltransferase activity] GO:0008168 [methyltransferase activity] GO:0010243 [response to organonitrogen compound] GO:0031100 [organ regeneration] GO:0032259 [methylation] GO:0042493 [response to drug] GO:0044281 [small molecule metabolic process] Show all	264 aa 29.6 kDa	No	0
NNMT-004 ENSP00000299964 ENST00000299964	P40261 [Direct mapping] Nicotinamide N-methyltransferase Q6FH49 [Target identity:100%; Query identity:100%] NNMT protein; Nicotinamide N-methyltransferase; Nicotinamide N-methyltransferase, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0006805 [xenobiotic metabolic process] GO:0008112 [nicotinamide N-methyltransferase activity] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] GO:0044281 [small molecule metabolic process] Show all	264 aa 29.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.