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NNMT

GENERAL INFORMATION

Gene name

 NNMT

Gene description

 Nicotinamide N-methyltransferase

Protein class

 Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (liver)
GTEx:Expressed in all
FANTOM5:Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a few tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA059180
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

 NNMT

Synonyms

Description

 Nicotinamide N-methyltransferase (HGNC Symbol)

Entrez gene summary

 N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q23.2

Chromosome location (bp)

 114257787 - 114313285

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166741 (version 83.38)

Entrez gene

 4837

UniProt

 P40261 (UniProt - Evidence at protein level)

neXtProt

 NX_P40261

Antibodypedia

 NNMT antibodies

PROTEIN BROWSER
NNMT-001
NNMT-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NNMT-001
ENSP00000441434
ENST00000535401
P40261 [Direct mapping]
Nicotinamide N-methyltransferase
Q6FH49 [Target identity:100%; Query identity:100%]
NNMT protein; Nicotinamide N-methyltransferase; Nicotinamide N-methyltransferase, isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0006805 [xenobiotic metabolic process]
GO:0008112 [nicotinamide N-methyltransferase activity]
GO:0008168 [methyltransferase activity]
GO:0010243 [response to organonitrogen compound]
GO:0031100 [organ regeneration]
GO:0032259 [methylation]
GO:0042493 [response to drug]
GO:0044281 [small molecule metabolic process]
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 264 aa
29.6 kDa 		No 0
NNMT-004
ENSP00000299964
ENST00000299964
P40261 [Direct mapping]
Nicotinamide N-methyltransferase
Q6FH49 [Target identity:100%; Query identity:100%]
NNMT protein; Nicotinamide N-methyltransferase; Nicotinamide N-methyltransferase, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0006805 [xenobiotic metabolic process]
GO:0008112 [nicotinamide N-methyltransferase activity]
GO:0008168 [methyltransferase activity]
GO:0032259 [methylation]
GO:0044281 [small molecule metabolic process]
Show all
 264 aa
29.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.