Cell atlas - CATSPER2 - The Human Protein Atlas

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CATSPER2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CATSPER2
Gene description	Cation channel, sperm associated 2
Protein class	Disease related genes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CATSPER2
Synonyms
Description	Cation channel, sperm associated 2 (HGNC Symbol)
Entrez gene summary	Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
Chromosome	15
Cytoband	q15.3
Chromosome location (bp)	43628503 - 43668118
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166762 (version 83.38)
Entrez gene	117155
UniProt	Q96P56 (UniProt - Evidence at protein level)
neXtProt	NX_Q96P56
Antibodypedia	CATSPER2 antibodies

PROTEIN BROWSER

CATSPER2-001	CATSPER2-002	CATSPER2-004	CATSPER2-009	CATSPER2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CATSPER2-001 ENSP00000380088 ENST00000396879	Q96P56 [Direct mapping] Cation channel sperm-associated protein 2 Show all	Voltage-gated ion channels CatSper and Two-Pore Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Show all	GO:0005216 [ion channel activity] GO:0005227 [calcium activated cation channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0007338 [single fertilization] GO:0016020 [membrane] GO:0030154 [cell differentiation] GO:0030317 [sperm motility] GO:0031514 [motile cilium] GO:0032504 [multicellular organism reproduction] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035036 [sperm-egg recognition] GO:0036128 [CatSper complex] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	528 aa 61.9 kDa	No	7
CATSPER2-002 ENSP00000321463 ENST00000321596	Q96P56 [Direct mapping] Cation channel sperm-associated protein 2 Show all	Voltage-gated ion channels CatSper and Two-Pore Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Show all	GO:0005216 [ion channel activity] GO:0005227 [calcium activated cation channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0007338 [single fertilization] GO:0016020 [membrane] GO:0030154 [cell differentiation] GO:0030317 [sperm motility] GO:0031514 [motile cilium] GO:0032504 [multicellular organism reproduction] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035036 [sperm-egg recognition] GO:0036128 [CatSper complex] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	530 aa 62 kDa	No	6
CATSPER2-004 ENSP00000371180 ENST00000381761	F8W9H2 [Direct mapping] Cation channel sperm-associated protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005227 [calcium activated cation channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0009566 [fertilization] GO:0016020 [membrane] GO:0030317 [sperm motility] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0036126 [sperm flagellum] GO:0036128 [CatSper complex] GO:0048240 [sperm capacitation] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	534 aa 62.5 kDa	No	7
CATSPER2-009 ENSP00000407694 ENST00000432420	E7EX46 [Direct mapping] Cation channel sperm-associated protein 2 Show all	Predicted intracellular proteins Show all	GO:0005227 [calcium activated cation channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005886 [plasma membrane] GO:0030317 [sperm motility] GO:0034220 [ion transmembrane transport] GO:0036128 [CatSper complex] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	80 aa 9.3 kDa	No	0
CATSPER2-010 ENSP00000386595 ENST00000409481	B8ZZQ9 [Direct mapping] Cation channel sperm-associated protein 2 Show all	Predicted intracellular proteins Show all	GO:0005227 [calcium activated cation channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005886 [plasma membrane] GO:0030317 [sperm motility] GO:0034220 [ion transmembrane transport] GO:0036128 [CatSper complex] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	64 aa 7.4 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.