Fields »
ABOUT
HELP
BLOG
CATSPER2

GENERAL INFORMATION

Gene name

 CATSPER2

Gene description

 Cation channel, sperm associated 2

Protein class

 Disease related genes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CATSPER2

Synonyms

Description

 Cation channel, sperm associated 2 (HGNC Symbol)

Entrez gene summary

 Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]

Chromosome

 15

Cytoband

 q15.3

Chromosome location (bp)

 43628503 - 43668118

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166762 (version 83.38)

Entrez gene

 117155

UniProt

 Q96P56 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96P56

Antibodypedia

 CATSPER2 antibodies

PROTEIN BROWSER
CATSPER2-001
CATSPER2-002
CATSPER2-004
CATSPER2-009
CATSPER2-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CATSPER2-001
ENSP00000380088
ENST00000396879
Q96P56 [Direct mapping]
Cation channel sperm-associated protein 2
Show all
Voltage-gated ion channels
   CatSper and Two-Pore Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Show all
GO:0005216 [ion channel activity]
GO:0005227 [calcium activated cation channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0007275 [multicellular organismal development]
GO:0007283 [spermatogenesis]
GO:0007338 [single fertilization]
GO:0016020 [membrane]
GO:0030154 [cell differentiation]
GO:0030317 [sperm motility]
GO:0031514 [motile cilium]
GO:0032504 [multicellular organism reproduction]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035036 [sperm-egg recognition]
GO:0036128 [CatSper complex]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 528 aa
61.9 kDa 		No 7
CATSPER2-002
ENSP00000321463
ENST00000321596
Q96P56 [Direct mapping]
Cation channel sperm-associated protein 2
Show all
Voltage-gated ion channels
   CatSper and Two-Pore Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Show all
GO:0005216 [ion channel activity]
GO:0005227 [calcium activated cation channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0007275 [multicellular organismal development]
GO:0007283 [spermatogenesis]
GO:0007338 [single fertilization]
GO:0016020 [membrane]
GO:0030154 [cell differentiation]
GO:0030317 [sperm motility]
GO:0031514 [motile cilium]
GO:0032504 [multicellular organism reproduction]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035036 [sperm-egg recognition]
GO:0036128 [CatSper complex]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 530 aa
62 kDa 		No 6
CATSPER2-004
ENSP00000371180
ENST00000381761
F8W9H2 [Direct mapping]
Cation channel sperm-associated protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005227 [calcium activated cation channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0009566 [fertilization]
GO:0016020 [membrane]
GO:0030317 [sperm motility]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0036126 [sperm flagellum]
GO:0036128 [CatSper complex]
GO:0048240 [sperm capacitation]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 534 aa
62.5 kDa 		No 7
CATSPER2-009
ENSP00000407694
ENST00000432420
E7EX46 [Direct mapping]
Cation channel sperm-associated protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005227 [calcium activated cation channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005886 [plasma membrane]
GO:0030317 [sperm motility]
GO:0034220 [ion transmembrane transport]
GO:0036128 [CatSper complex]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 80 aa
9.3 kDa 		No 0
CATSPER2-010
ENSP00000386595
ENST00000409481
B8ZZQ9 [Direct mapping]
Cation channel sperm-associated protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005227 [calcium activated cation channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005886 [plasma membrane]
GO:0030317 [sperm motility]
GO:0034220 [ion transmembrane transport]
GO:0036128 [CatSper complex]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
 64 aa
7.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.