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LDHD

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GENERAL INFORMATION

Gene name

 LDHD

Gene description

 Lactate dehydrogenase D

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol.

RNA cell category

 Cell line enhanced (T-47d, HMC-1)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA066148
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (T-47d, HMC-1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol.

Main location

 Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA066148 Hep G2 Cytosol
HPA066148 MCF7 Cytosol Intensity
HPA066148 U-2 OS Cytosol

GENE INFORMATION

Gene name

 LDHD

Synonyms

Description

 Lactate dehydrogenase D (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. The similar protein in yeast has both D-lactate and D-glycerate dehydrogenase activities. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q23.1

Chromosome location (bp)

 75111860 - 75116771

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166816 (version 83.38)

Entrez gene

 197257

UniProt

 Q86WU2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86WU2

Antibodypedia

 LDHD antibodies

PROTEIN BROWSER
LDHD-001
LDHD-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LDHD-001
ENSP00000300051
ENST00000300051
Q86WU2 [Direct mapping]
Probable D-lactate dehydrogenase, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004458 [D-lactate dehydrogenase (cytochrome) activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0016491 [oxidoreductase activity]
GO:0016614 [oxidoreductase activity, acting on CH-OH group of donors]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
 507 aa
54.9 kDa 		No 0
LDHD-002
ENSP00000417011
ENST00000450168
Q86WU2 [Direct mapping]
Probable D-lactate dehydrogenase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004458 [D-lactate dehydrogenase (cytochrome) activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0016491 [oxidoreductase activity]
GO:0016614 [oxidoreductase activity, acting on CH-OH group of donors]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
 484 aa
52.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.