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LDHD

GENERAL INFORMATION

Gene name

 LDHD

Gene description

 Lactate dehydrogenase D

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HMC-1, T-47d)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA041766 , HPA048639
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and liver cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA041766
HPA048639

GENE INFORMATION

Gene name

 LDHD

Synonyms

Description

 Lactate dehydrogenase D (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. The similar protein in yeast has both D-lactate and D-glycerate dehydrogenase activities. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q23.1

Chromosome location (bp)

 75111860 - 75116771

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166816 (version 83.38)

Entrez gene

 197257

UniProt

 Q86WU2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86WU2

Antibodypedia

 LDHD antibodies

PROTEIN BROWSER
LDHD-001
LDHD-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LDHD-001
ENSP00000300051
ENST00000300051
Q86WU2 [Direct mapping]
Probable D-lactate dehydrogenase, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0004458 [D-lactate dehydrogenase (cytochrome) activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0016491 [oxidoreductase activity]
GO:0016614 [oxidoreductase activity, acting on CH-OH group of donors]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
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 507 aa
54.9 kDa 		No 0
LDHD-002
ENSP00000417011
ENST00000450168
Q86WU2 [Direct mapping]
Probable D-lactate dehydrogenase, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004458 [D-lactate dehydrogenase (cytochrome) activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0016491 [oxidoreductase activity]
GO:0016614 [oxidoreductase activity, acting on CH-OH group of donors]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
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 484 aa
52.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.