Cell atlas - SCNN1G - The Human Protein Atlas

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SCNN1G

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleoplasm
	Plasma membrane

Human cell
	Nucleoli
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	SCNN1G
Gene description	Sodium channel, non voltage gated 1 gamma subunit
Protein class	Disease related genes FDA approved drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli & plasma membrane. In addition localized to the nucleoplasm.
RNA cell category	Group enriched (hTCEpi, RT4)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved), Plasma membrane (approved)
Additional location	In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA071194
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (hTCEpi, RT4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli & plasma membrane. In addition localized to the nucleoplasm.

Main location

Nucleoli (approved), Plasma membrane (approved)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA071194	PC-3	Nucleoli
	HPA071194	RT4	Nucleoplasm
	HPA071194	RT4	Plasma membrane

GENE INFORMATION
Gene name	SCNN1G (HGNC Symbol)
Synonyms	ENaCgamma, SCNEG
Description	Sodium channel, non voltage gated 1 gamma subunit (HGNC Symbol)
Entrez gene summary	Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009]
Chromosome	16
Cytoband	p12.2
Chromosome location (bp)	23182715 - 23216883
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166828 (version 83.38)
Entrez gene	6340
UniProt	P51170 (UniProt - Evidence at protein level)
neXtProt	NX_P51170
Antibodypedia	SCNN1G antibodies

PROTEIN BROWSER

SCNN1G-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCNN1G-001 ENSP00000300061 ENST00000300061	P51170 [Direct mapping] Amiloride-sensitive sodium channel subunit gamma A5X2V1 [Target identity:100%; Query identity:100%] Amiloride-sensitive sodium channel gamma-subunit; Nasal epithelial sodium channel gamma subunit; Sodium channel, nonvoltage-gated 1, gamma, isoform CRA_a Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0005216 [ion channel activity] GO:0005272 [sodium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006814 [sodium ion transport] GO:0007588 [excretion] GO:0009897 [external side of plasma membrane] GO:0015280 [ligand-gated sodium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0034220 [ion transmembrane transport] GO:0034706 [sodium channel complex] GO:0035725 [sodium ion transmembrane transport] GO:0050699 [WW domain binding] GO:0050891 [multicellular organismal water homeostasis] GO:0050896 [response to stimulus] GO:0050909 [sensory perception of taste] GO:0055078 [sodium ion homeostasis] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	649 aa 74.3 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.