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SCNN1G

GENERAL INFORMATION

Gene name

 SCNN1G

Gene description

 Sodium channel, non voltage gated 1 gamma subunit

Protein class

 Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (urothelial cancer)
HPA (cell line):Group enriched (hTCEpi, RT4)
HPA (normal tissue):Tissue enhanced (cervix, uterine, kidney)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (urothelial cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 SCNN1G (HGNC Symbol)

Synonyms

 ENaCgamma, SCNEG

Description

 Sodium channel, non voltage gated 1 gamma subunit (HGNC Symbol)

Entrez gene summary

 Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009]

Chromosome

 16

Cytoband

 p12.2

Chromosome location (bp)

 23182715 - 23216883

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166828 (version 83.38)

Entrez gene

 6340

UniProt

 P51170 (UniProt - Evidence at protein level)

neXtProt

 NX_P51170

Antibodypedia

 SCNN1G antibodies

PROTEIN BROWSER
SCNN1G-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SCNN1G-001
ENSP00000300061
ENST00000300061
P51170 [Direct mapping]
Amiloride-sensitive sodium channel subunit gamma
A5X2V1 [Target identity:100%; Query identity:100%]
Amiloride-sensitive sodium channel gamma-subunit; Nasal epithelial sodium channel gamma subunit; Sodium channel, nonvoltage-gated 1, gamma, isoform CRA_a
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
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GO:0005216 [ion channel activity]
GO:0005272 [sodium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006814 [sodium ion transport]
GO:0007588 [excretion]
GO:0009897 [external side of plasma membrane]
GO:0015280 [ligand-gated sodium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0034220 [ion transmembrane transport]
GO:0034706 [sodium channel complex]
GO:0035725 [sodium ion transmembrane transport]
GO:0050699 [WW domain binding]
GO:0050891 [multicellular organismal water homeostasis]
GO:0050896 [response to stimulus]
GO:0050909 [sensory perception of taste]
GO:0055078 [sodium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
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 649 aa
74.3 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.