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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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TERF2IP
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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

TERF2IP

Gene description

Telomeric repeat binding factor 2, interacting protein

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA006719 , CAB018660 , CAB018749
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable), ovarian cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Ovarian cancer p<0.001
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA006719
CAB018660
CAB018749

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of cancer tissues showed weak to moderate nuclear and cytoplasmic positivity. Gliomas and lymphomas displayed strong nuclear immunoreactivity. A majority of renal carcinomas were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Gliomas and lymphomas showed moderate to strong nuclear immunoreactivity. The remaining cancers exhibited weak to moderate nuclear positivity or were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant gliomas exhibited moderate to strong nuclear immunoreactivity. The remaining tumors were generally negative or weakly stained.

GENE INFORMATION

Gene name

TERF2IP (HGNC Symbol)

Synonyms

RAP1

Description

Telomeric repeat binding factor 2, interacting protein (HGNC Symbol)

Entrez gene summary

The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010]

Chromosome

16

Cytoband

q23.1

Chromosome location (bp)

75647786 - 75761872

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166848 (version 83.38)

Entrez gene

54386

UniProt

Q9NYB0 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NYB0

Antibodypedia

TERF2IP antibodies

PROTEIN BROWSER

TERF2IP-001
TERF2IP-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TERF2IP-001
ENSP00000300086
ENST00000300086
Q9NYB0 [Direct mapping]
Telomeric repeat-binding factor 2-interacting protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000228 [nuclear chromosome]
GO:0000723 [telomere maintenance]
GO:0000781 [chromosome, telomeric region]
GO:0000783 [nuclear telomere cap complex]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007004 [telomere maintenance via telomerase]
GO:0010569 [regulation of double-strand break repair via homologous recombination]
GO:0010833 [telomere maintenance via telomere lengthening]
GO:0030870 [Mre11 complex]
GO:0031848 [protection from non-homologous end joining at telomere]
GO:0032205 [negative regulation of telomere maintenance]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0048239 [negative regulation of DNA recombination at telomere]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0070187 [telosome]
GO:0070198 [protein localization to chromosome, telomeric region]
GO:1901985 [positive regulation of protein acetylation]
Show all
399 aa
44.3 kDa
No 0
TERF2IP-003
ENSP00000456092
ENST00000564671
H3BR63 [Direct mapping]
Telomeric repeat-binding factor 2-interacting protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
122 aa
13.3 kDa
No 0

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