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CHP2

GENERAL INFORMATION

Gene name

 CHP2

Gene description

 Calcineurin-like EF-hand protein 2

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (colorectal cancer)
HPA (cell line):Cell line enhanced (NB-4)
HPA (normal tissue):Group enriched (colon, duodenum, rectum, skin, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB072806
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (colorectal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB072806

GENE INFORMATION

Gene name

 CHP2

Synonyms

Description

 Calcineurin-like EF-hand protein 2 (HGNC Symbol)

Entrez gene summary

 This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013]

Chromosome

 16

Cytoband

 p12.2

Chromosome location (bp)

 23754627 - 23758951

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166869 (version 83.38)

Entrez gene

 63928

UniProt

 O43745 (UniProt - Evidence at protein level)

neXtProt

 NX_O43745

Antibodypedia

 CHP2 antibodies

PROTEIN BROWSER
CHP2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHP2-001
ENSP00000300113
ENST00000300113
O43745 [Direct mapping]
Calcineurin B homologous protein 2
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008284 [positive regulation of cell proliferation]
GO:0010922 [positive regulation of phosphatase activity]
GO:0015031 [protein transport]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade]
GO:0071277 [cellular response to calcium ion]
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 196 aa
22.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.