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RNA tissue category: Group enriched (colon, duodenum, rectum, skin, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, skin, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, small intestine)
GENE INFORMATION
Gene name
CHP2
Synonyms
Description
Calcineurin-like EF-hand protein 2 (HGNC Symbol)
Entrez gene summary
This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013]
O43745 [Direct mapping] Calcineurin B homologous protein 2
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Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0008284 [positive regulation of cell proliferation] GO:0010922 [positive regulation of phosphatase activity] GO:0015031 [protein transport] GO:0042307 [positive regulation of protein import into nucleus] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade] GO:0071277 [cellular response to calcium ion]
