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STAT6

GENERAL INFORMATION

Gene name

 STAT6

Gene description

 Signal transducer and activator of transcription 6, interleukin-4 induced

Protein class

 Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 17
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA001861
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable), endometrial cancer (favourable) and thyroid cancer (favourable).
Urothelial cancer p<0.001
Endometrial cancer p<0.001
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001861

GENE INFORMATION

Gene name

 STAT6 (HGNC Symbol)

Synonyms

 D12S1644, IL-4-STAT

Description

 Signal transducer and activator of transcription 6, interleukin-4 induced (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Chromosome

 12

Cytoband

 q13.3

Chromosome location (bp)

 57095408 - 57132139

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166888 (version 83.38)

Entrez gene

 6778

UniProt

 P42226 (UniProt - Evidence at protein level)

neXtProt

 NX_P42226

Antibodypedia

 STAT6 antibodies

PROTEIN BROWSER
«
STAT6-001
STAT6-002
STAT6-003
STAT6-004
STAT6-006
STAT6-008
STAT6-010
STAT6-013
STAT6-014
STAT6-015
STAT6-018
STAT6-019
STAT6-020
STAT6-021
STAT6-022
STAT6-023
STAT6-024
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STAT6-001
ENSP00000300134
ENST00000300134
P42226 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0002296 [T-helper 1 cell lineage commitment]
GO:0002829 [negative regulation of type 2 immune response]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019903 [protein phosphatase binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0033598 [mammary gland epithelial cell proliferation]
GO:0034097 [response to cytokine]
GO:0035771 [interleukin-4-mediated signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042802 [identical protein binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048295 [positive regulation of isotype switching to IgE isotypes]
GO:0060443 [mammary gland morphogenesis]
GO:0070301 [cellular response to hydrogen peroxide]
GO:1902170 [cellular response to reactive nitrogen species]
Show all
 847 aa
94.1 kDa 		No 0
STAT6-002
ENSP00000451742
ENST00000556155
P42226 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0019903 [protein phosphatase binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0035771 [interleukin-4-mediated signaling pathway]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
Show all
 847 aa
94.1 kDa 		No 0
STAT6-003
ENSP00000438451
ENST00000543873
P42226 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0019903 [protein phosphatase binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0035771 [interleukin-4-mediated signaling pathway]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
Show all
 847 aa
94.1 kDa 		No 0
STAT6-004
ENSP00000401486
ENST00000454075
P42226 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0019903 [protein phosphatase binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0035771 [interleukin-4-mediated signaling pathway]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
Show all
 847 aa
94.1 kDa 		No 0
STAT6-006
ENSP00000444530
ENST00000537215
P42226 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0019903 [protein phosphatase binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0035771 [interleukin-4-mediated signaling pathway]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
Show all
 737 aa
81.7 kDa 		No 0
STAT6-008
ENSP00000445409
ENST00000538913
P42226 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0019903 [protein phosphatase binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0035771 [interleukin-4-mediated signaling pathway]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
Show all
 737 aa
81.7 kDa 		No 0
STAT6-010
ENSP00000451074
ENST00000553499
G3V370 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 154 aa
17.8 kDa 		No 0
STAT6-013
ENSP00000450428
ENST00000555318
H0YIY2 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 155 aa
17.3 kDa 		No 0
STAT6-014
ENSP00000451546
ENST00000553533
H0YJH6 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 290 aa
32.5 kDa 		No 0
STAT6-015
ENSP00000450921
ENST00000555375
G3V2X7 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 154 aa
17.9 kDa 		No 0
STAT6-018
ENSP00000450732
ENST00000553275
G3V2L2 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 64 aa
7.4 kDa 		No 0
STAT6-019
ENSP00000451209
ENST00000554825
G3V3E9 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 103 aa
11.7 kDa 		No 0
STAT6-020
ENSP00000452203
ENST00000553397
G3V568 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 144 aa
16.7 kDa 		No 0
STAT6-021
ENSP00000452394
ENST00000555849
G3V5K5 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 159 aa
18.3 kDa 		No 0
STAT6-022
ENSP00000450747
ENST00000557635
G3V2M3 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 74 aa
8.3 kDa 		No 0
STAT6-023
ENSP00000450665
ENST00000554663
G3V2H4 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 105 aa
11.8 kDa 		No 0
STAT6-024
ENSP00000452373
ENST00000556259
G3V5I8 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
 141 aa
16.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.