Expression of MARS in cancer - Summary - The Human Protein Atlas

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MARS

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MARS
Gene description	Methionyl-tRNA synthetase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA004125 , CAB017097
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and breast cancer (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA004125	CAB017097

GENE INFORMATION
Gene name	MARS (HGNC Symbol)
Synonyms	CMT2U, MetRS, SPG70
Description	Methionyl-tRNA synthetase (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. [provided by RefSeq, Jan 2011]
Chromosome	12
Cytoband	q13.3
Chromosome location (bp)	57475445 - 57517569
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166986 (version 83.38)
Entrez gene	4141
UniProt	P56192 (UniProt - Evidence at protein level)
neXtProt	NX_P56192
Antibodypedia	MARS antibodies

PROTEIN BROWSER

MARS-003	MARS-021	MARS-030	MARS-033	MARS-034	MARS-201	MARS-202	MARS-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MARS-003 ENSP00000262027 ENST00000262027	P56192 [Direct mapping] Methionine--tRNA ligase, cytoplasmic Show all	Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004825 [methionine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006431 [methionyl-tRNA aminoacylation] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0070062 [extracellular exosome] Show all	900 aa 101.1 kDa	No	0
MARS-021 ENSP00000447914 ENST00000552371	H0YHV5 [Direct mapping] Methionine--tRNA ligase, cytoplasmic Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004825 [methionine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006431 [methionyl-tRNA aminoacylation] Show all	233 aa 26.6 kDa	No	0
MARS-030 ENSP00000449787 ENST00000552914	H0YIP0 [Direct mapping] Methionine--tRNA ligase, cytoplasmic Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006431 [methionyl-tRNA aminoacylation] Show all	219 aa 24.3 kDa	No	0
MARS-033 ENSP00000448910 ENST00000547665	H0YI94 [Direct mapping] Methionine--tRNA ligase, cytoplasmic Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006431 [methionyl-tRNA aminoacylation] Show all	119 aa 12.6 kDa	No	1
MARS-034 ENSP00000449071 ENST00000548944	H0YIC2 [Direct mapping] Methionine--tRNA ligase, cytoplasmic Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006431 [methionyl-tRNA aminoacylation] Show all	58 aa 6.4 kDa	No	0
MARS-201 ENSP00000486738 ENST00000628866	F8W0M7 [Direct mapping] Methionine--tRNA ligase, cytoplasmic Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0006431 [methionyl-tRNA aminoacylation] Show all	95 aa 10.6 kDa	No	0
MARS-202 ENSP00000485951 ENST00000630571	F8VS26 [Direct mapping] Methionine--tRNA ligase, cytoplasmic Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0006431 [methionyl-tRNA aminoacylation] Show all	71 aa 7.6 kDa	No	0
MARS-203 ENSP00000486356 ENST00000630803	F8VPL7 [Direct mapping] Methionine--tRNA ligase, cytoplasmic Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0006431 [methionyl-tRNA aminoacylation] Show all	60 aa 6.1 kDa	No	0

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