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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SNRPD1
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SNRPD1

Gene description

Small nuclear ribonucleoprotein D1 polypeptide 16kDa

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA040516
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PROGNOSTIC SUMMARY

Prognostic marker in ovarian cancer (favourable) and liver cancer (unfavourable).
Ovarian cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA040516

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues displayed weak to moderate nuclear positivity.

GENE INFORMATION

Gene name

SNRPD1 (HGNC Symbol)

Synonyms

HsT2456, Sm-D1, SNRPD

Description

Small nuclear ribonucleoprotein D1 polypeptide 16kDa (HGNC Symbol)

Entrez gene summary

This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Chromosome

18

Cytoband

q11.2

Chromosome location (bp)

21612267 - 21633524

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167088 (version 83.38)

Entrez gene

6632

UniProt

P62314 (UniProt - Evidence at protein level)

neXtProt

NX_P62314

Antibodypedia

SNRPD1 antibodies

PROTEIN BROWSER

SNRPD1-001
SNRPD1-002
SNRPD1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SNRPD1-001
ENSP00000300413
ENST00000300413
P62314 [Direct mapping]
Small nuclear ribonucleoprotein Sm D1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000243 [commitment complex]
GO:0000245 [spliceosomal complex assembly]
GO:0000387 [spliceosomal snRNP assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005682 [U5 snRNP]
GO:0005685 [U1 snRNP]
GO:0005686 [U2 snRNP]
GO:0005687 [U4 snRNP]
GO:0005689 [U12-type spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0030532 [small nuclear ribonucleoprotein complex]
GO:0034660 [ncRNA metabolic process]
GO:0034709 [methylosome]
GO:0034715 [pICln-Sm protein complex]
GO:0034719 [SMN-Sm protein complex]
GO:0044822 [poly(A) RNA binding]
GO:0071010 [prespliceosome]
GO:0071011 [precatalytic spliceosome]
GO:0071013 [catalytic step 2 spliceosome]
GO:0097526 [spliceosomal tri-snRNP complex]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
119 aa
13.3 kDa
No 0
SNRPD1-002
ENSP00000463568
ENST00000582475
J3QLI9 [Direct mapping]
Small nuclear ribonucleoprotein Sm D1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006396 [RNA processing]
Show all
75 aa
8.4 kDa
No 0
SNRPD1-003
ENSP00000463676
ENST00000579618
J3QLR7 [Direct mapping]
Small nuclear ribonucleoprotein Sm D1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006396 [RNA processing]
Show all
44 aa
5.3 kDa
No 0

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