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TRUB2

GENERAL INFORMATION

Gene name

 TRUB2

Gene description

 TruB pseudouridine (psi) synthase family member 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA021211
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021211

GENE INFORMATION

Gene name

 TRUB2 (HGNC Symbol)

Synonyms

 CLONE24922

Description

 TruB pseudouridine (psi) synthase family member 2 (HGNC Symbol)

Entrez gene summary

 Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).[supplied by OMIM, Mar 2008]

Chromosome

 9

Cytoband

 q34.11

Chromosome location (bp)

 128305161 - 128322742

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167112 (version 83.38)

Entrez gene

 26995

UniProt

 O95900 (UniProt - Evidence at protein level)

neXtProt

 NX_O95900

Antibodypedia

 TRUB2 antibodies

PROTEIN BROWSER
TRUB2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRUB2-001
ENSP00000361982
ENST00000372890
O95900 [Direct mapping]
Probable tRNA pseudouridine synthase 2
A0A024R886 [Target identity:100%; Query identity:100%]
TruB pseudouridine (Psi) synthase homolog 2 (E. coli), isoform CRA_a
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0001522 [pseudouridine synthesis]
GO:0003723 [RNA binding]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0008033 [tRNA processing]
GO:0009451 [RNA modification]
GO:0009982 [pseudouridine synthase activity]
GO:0044822 [poly(A) RNA binding]
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 331 aa
36.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.