Cell atlas - CDK12 - The Human Protein Atlas

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CDK12

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CDK12
Gene description	Cyclin-dependent kinase 12
Protein class	Cancer-related genes Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA008038
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus.

Main location

Nucleus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA008038	A-431	Nucleoplasm
	HPA008038	U-2 OS	Nucleus
	HPA008038	U-251 MG	Nucleoplasm
	HPA008038	U-251 MG	Nucleoli fibrillar center

GENE INFORMATION
Gene name	CDK12 (HGNC Symbol)
Synonyms	CRK7, CRKR, CRKRS, KIAA0904
Description	Cyclin-dependent kinase 12 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q12
Chromosome location (bp)	39461511 - 39564907
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167258 (version 83.38)
Entrez gene	51755
UniProt	Q9NYV4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NYV4
Antibodypedia	CDK12 antibodies

PROTEIN BROWSER

CDK12-001	CDK12-008	CDK12-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDK12-001 ENSP00000398880 ENST00000447079	Q9NYV4 [Direct mapping] Cyclin-dependent kinase 12 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002944 [cyclin K-CDK12 complex] GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006397 [mRNA processing] GO:0006468 [protein phosphorylation] GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity] GO:0008380 [RNA splicing] GO:0016607 [nuclear speck] GO:0019908 [nuclear cyclin-dependent protein kinase holoenzyme complex] GO:0030332 [cyclin binding] GO:0043405 [regulation of MAP kinase activity] GO:0043484 [regulation of RNA splicing] GO:0046777 [protein autophosphorylation] GO:0051726 [regulation of cell cycle] GO:0070816 [phosphorylation of RNA polymerase II C-terminal domain] Show all	1490 aa 164.2 kDa	No	0
CDK12-008 ENSP00000407720 ENST00000430627	Q9NYV4 [Direct mapping] Cyclin-dependent kinase 12 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002944 [cyclin K-CDK12 complex] GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006397 [mRNA processing] GO:0006468 [protein phosphorylation] GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity] GO:0008380 [RNA splicing] GO:0016607 [nuclear speck] GO:0019908 [nuclear cyclin-dependent protein kinase holoenzyme complex] GO:0030332 [cyclin binding] GO:0043405 [regulation of MAP kinase activity] GO:0046777 [protein autophosphorylation] GO:0051726 [regulation of cell cycle] GO:0070816 [phosphorylation of RNA polymerase II C-terminal domain] Show all	1481 aa 163.2 kDa	No	0
CDK12-010 ENSP00000464641 ENST00000584632	J3QSD7 [Direct mapping] Cyclin-dependent kinase 12 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	1201 aa 133.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.