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CDK12

GENERAL INFORMATION

Gene name

 CDK12

Gene description

 Cyclin-dependent kinase 12

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA008038
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CDK12 (HGNC Symbol)

Synonyms

 CRK7, CRKR, CRKRS, KIAA0904

Description

 Cyclin-dependent kinase 12 (HGNC Symbol)

Entrez gene summary

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 39461511 - 39564907

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167258 (version 83.38)

Entrez gene

 51755

UniProt

 Q9NYV4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NYV4

Antibodypedia

 CDK12 antibodies

PROTEIN BROWSER
CDK12-001
CDK12-008
CDK12-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDK12-001
ENSP00000398880
ENST00000447079
Q9NYV4 [Direct mapping]
Cyclin-dependent kinase 12
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002944 [cyclin K-CDK12 complex]
GO:0004672 [protein kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006397 [mRNA processing]
GO:0006468 [protein phosphorylation]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0008380 [RNA splicing]
GO:0016607 [nuclear speck]
GO:0019908 [nuclear cyclin-dependent protein kinase holoenzyme complex]
GO:0030332 [cyclin binding]
GO:0043405 [regulation of MAP kinase activity]
GO:0043484 [regulation of RNA splicing]
GO:0046777 [protein autophosphorylation]
GO:0051726 [regulation of cell cycle]
GO:0070816 [phosphorylation of RNA polymerase II C-terminal domain]
Show all
 1490 aa
164.2 kDa 		No 0
CDK12-008
ENSP00000407720
ENST00000430627
Q9NYV4 [Direct mapping]
Cyclin-dependent kinase 12
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002944 [cyclin K-CDK12 complex]
GO:0004672 [protein kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006397 [mRNA processing]
GO:0006468 [protein phosphorylation]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0008380 [RNA splicing]
GO:0016607 [nuclear speck]
GO:0019908 [nuclear cyclin-dependent protein kinase holoenzyme complex]
GO:0030332 [cyclin binding]
GO:0043405 [regulation of MAP kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0051726 [regulation of cell cycle]
GO:0070816 [phosphorylation of RNA polymerase II C-terminal domain]
Show all
 1481 aa
163.2 kDa 		No 0
CDK12-010
ENSP00000464641
ENST00000584632
J3QSD7 [Direct mapping]
Cyclin-dependent kinase 12
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 1201 aa
133.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.