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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CDK12
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    TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CDK12

Gene description

Cyclin-dependent kinase 12

Protein class

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General nuclear expression.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA008038
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

CDK12 (HGNC Symbol)

Synonyms

CRK7, CRKR, CRKRS, KIAA0904

Description

Cyclin-dependent kinase 12 (HGNC Symbol)

Entrez gene summary

Chromosome

17

Cytoband

q12

Chromosome location (bp)

39461511 - 39564907

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167258 (version 83.38)

Entrez gene

51755

UniProt

Q9NYV4 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NYV4

Antibodypedia

CDK12 antibodies

PROTEIN BROWSER

CDK12-001
CDK12-008
CDK12-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDK12-001
ENSP00000398880
ENST00000447079
Q9NYV4 [Direct mapping]
Cyclin-dependent kinase 12
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002944 [cyclin K-CDK12 complex]
GO:0004672 [protein kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006397 [mRNA processing]
GO:0006468 [protein phosphorylation]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0008380 [RNA splicing]
GO:0016607 [nuclear speck]
GO:0019908 [nuclear cyclin-dependent protein kinase holoenzyme complex]
GO:0030332 [cyclin binding]
GO:0043405 [regulation of MAP kinase activity]
GO:0043484 [regulation of RNA splicing]
GO:0046777 [protein autophosphorylation]
GO:0051726 [regulation of cell cycle]
GO:0070816 [phosphorylation of RNA polymerase II C-terminal domain]
Show all
1490 aa
164.2 kDa
No 0
CDK12-008
ENSP00000407720
ENST00000430627
Q9NYV4 [Direct mapping]
Cyclin-dependent kinase 12
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002944 [cyclin K-CDK12 complex]
GO:0004672 [protein kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006397 [mRNA processing]
GO:0006468 [protein phosphorylation]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0008380 [RNA splicing]
GO:0016607 [nuclear speck]
GO:0019908 [nuclear cyclin-dependent protein kinase holoenzyme complex]
GO:0030332 [cyclin binding]
GO:0043405 [regulation of MAP kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0051726 [regulation of cell cycle]
GO:0070816 [phosphorylation of RNA polymerase II C-terminal domain]
Show all
1481 aa
163.2 kDa
No 0
CDK12-010
ENSP00000464641
ENST00000584632
J3QSD7 [Direct mapping]
Cyclin-dependent kinase 12
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
1201 aa
133.7 kDa
No 0

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