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MYO5B

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GENERAL INFORMATION

Gene name

 MYO5B

Gene description

 Myosin VB

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane.

RNA cell category

 Cell line enhanced (RH-30, HaCaT)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA069773
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RH-30, HaCaT)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane.

Main location

 Plasma membrane (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA069773 HaCaT Plasma membrane
HPA069773 RH-30 No staining    
HPA069773 U-2 OS Plasma membrane

GENE INFORMATION

Gene name

 MYO5B (HGNC Symbol)

Synonyms

 KIAA1119

Description

 Myosin VB (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene, together with other proteins, may be involved in plasma membrane recycling. Mutations in this gene are associated with microvillous inclusion disease. [provided by RefSeq, Sep 2009]

Chromosome

 18

Cytoband

 q21.1

Chromosome location (bp)

 49822813 - 50195093

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167306 (version 83.38)

Entrez gene

 4645

UniProt

 Q9ULV0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9ULV0

Antibodypedia

 MYO5B antibodies

PROTEIN BROWSER
MYO5B-001
MYO5B-002
MYO5B-006
MYO5B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYO5B-001
ENSP00000285039
ENST00000285039
Q9ULV0 [Direct mapping]
Unconventional myosin-Vb
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0003091 [renal water homeostasis]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0006833 [water transport]
GO:0008152 [metabolic process]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0016459 [myosin complex]
GO:0017137 [Rab GTPase binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0032439 [endosome localization]
GO:0043234 [protein complex]
GO:0045179 [apical cortex]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
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 1848 aa
213.7 kDa 		No 0
MYO5B-002
ENSP00000466368
ENST00000592688
Q9ULV0 [Direct mapping]
Unconventional myosin-Vb
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0003091 [renal water homeostasis]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0006833 [water transport]
GO:0008152 [metabolic process]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0016459 [myosin complex]
GO:0017137 [Rab GTPase binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0032439 [endosome localization]
GO:0043234 [protein complex]
GO:0045179 [apical cortex]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
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 418 aa
48 kDa 		No 0
MYO5B-006
ENSP00000315531
ENST00000324581
A0A0A0MR36 [Direct mapping]
Unconventional myosin-Vb
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 965 aa
112 kDa 		No 0
MYO5B-201
ENSP00000479038
ENST00000616031
Q7Z7A5 [Direct mapping]
Myosin 5B; Unconventional myosin-Vb
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
Show all
 720 aa
82.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.