Expression of ACAA2 in cancer - Summary - The Human Protein Atlas

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ACAA2

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACAA2
Gene description	Acetyl-CoA acyltransferase 2
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with granular pattern in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA042303
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042303

GENE INFORMATION
Gene name	ACAA2 (HGNC Symbol)
Synonyms	DSAEC
Description	Acetyl-CoA acyltransferase 2 (HGNC Symbol)
Entrez gene summary	The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal. [provided by RefSeq, Jul 2008]
Chromosome	18
Cytoband	q21.1
Chromosome location (bp)	49782167 - 49813960
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167315 (version 83.38)
Entrez gene	10449
UniProt	P42765 (UniProt - Evidence at protein level)
neXtProt	NX_P42765
Antibodypedia	ACAA2 antibodies

PROTEIN BROWSER

ACAA2-001	ACAA2-003	ACAA2-004	ACAA2-005	ACAA2-006	ACAA2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACAA2-001 ENSP00000285093 ENST00000285093	P42765 [Direct mapping] 3-ketoacyl-CoA thiolase, mitochondrial Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003988 [acetyl-CoA C-acyltransferase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006631 [fatty acid metabolic process] GO:0006695 [cholesterol biosynthetic process] GO:0008152 [metabolic process] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] GO:0071456 [cellular response to hypoxia] GO:1901029 [negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] GO:1902109 [negative regulation of mitochondrial membrane permeability involved in apoptotic process] Show all	397 aa 41.9 kDa	No	0
ACAA2-003 ENSP00000466015 ENST00000587994	A0A0B4J2A4 [Direct mapping] 3-ketoacyl-CoA thiolase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] Show all	394 aa 41.6 kDa	No	0
ACAA2-004 ENSP00000468157 ENST00000586100	K7ER88 [Direct mapping] 3-ketoacyl-CoA thiolase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] Show all	72 aa 7.6 kDa	No	0
ACAA2-005 ENSP00000465095 ENST00000585948	K7EJB1 [Direct mapping] 3-ketoacyl-CoA thiolase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] Show all	84 aa 8.9 kDa	No	0
ACAA2-006 ENSP00000465045 ENST00000586485	K7EJ68 [Direct mapping] 3-ketoacyl-CoA thiolase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] Show all	124 aa 13.5 kDa	No	0
ACAA2-007 ENSP00000466466 ENST00000589432	K7EME0 [Direct mapping] 3-ketoacyl-CoA thiolase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] Show all	342 aa 36.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.