Expression of TPM4 in cancer - Summary - The Human Protein Atlas

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TPM4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TPM4
Gene description	Tropomyosin 4
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Approved based on 3 antibodies. HPA047089 , HPA053624 , CAB004685
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047089	HPA053624	CAB004685

GENE INFORMATION
Gene name	TPM4
Synonyms
Description	Tropomyosin 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Chromosome	19
Cytoband
Chromosome location (bp)	16067021 - 16103005
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167460 (version 83.38)
Entrez gene	7171
UniProt	P67936 (UniProt - Evidence at protein level)
neXtProt	NX_P67936
Antibodypedia	TPM4 antibodies

PROTEIN BROWSER

TPM4-001	TPM4-002	TPM4-007	TPM4-008	TPM4-009	TPM4-010	TPM4-012	TPM4-014	TPM4-015	TPM4-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TPM4-001 ENSP00000345230 ENST00000344824	P67936 [Direct mapping] Tropomyosin alpha-4 chain Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001649 [osteoblast differentiation] GO:0001725 [stress fiber] GO:0002102 [podosome] GO:0003779 [actin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005862 [muscle thin filament tropomyosin] GO:0005925 [focal adhesion] GO:0006928 [movement of cell or subcellular component] GO:0006936 [muscle contraction] GO:0008307 [structural constituent of muscle] GO:0016020 [membrane] GO:0030049 [muscle filament sliding] GO:0030863 [cortical cytoskeleton] GO:0031941 [filamentous actin] GO:0070062 [extracellular exosome] Show all	284 aa 32.7 kDa	No	0
TPM4-002 ENSP00000300933 ENST00000300933	P67936 [Direct mapping] Tropomyosin alpha-4 chain V9HW56 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 108; Tropomyosin 4, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001649 [osteoblast differentiation] GO:0001725 [stress fiber] GO:0003779 [actin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005862 [muscle thin filament tropomyosin] GO:0005925 [focal adhesion] GO:0006928 [movement of cell or subcellular component] GO:0006936 [muscle contraction] GO:0008307 [structural constituent of muscle] GO:0016020 [membrane] GO:0030049 [muscle filament sliding] GO:0070062 [extracellular exosome] Show all	248 aa 28.5 kDa	No	0
TPM4-007 ENSP00000466158 ENST00000589897	K7ELP0 [Direct mapping] Tropomyosin alpha-4 chain Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		69 aa 8 kDa	No	0
TPM4-008 ENSP00000468246 ENST00000586499	K7ERG3 [Direct mapping] Tropomyosin alpha-4 chain Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		170 aa 19.3 kDa	No	0
TPM4-009 ENSP00000467087 ENST00000586833	K7ENT6 [Direct mapping] Tropomyosin alpha-4 chain Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		179 aa 20.6 kDa	No	0
TPM4-010 ENSP00000467558 ENST00000588507	K7EPV9 [Direct mapping] Tropomyosin alpha-4 chain Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		96 aa 11.3 kDa	No	0
TPM4-012 ENSP00000467250 ENST00000588410	K7EP68 [Direct mapping] Tropomyosin alpha-4 chain Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		138 aa 15.8 kDa	No	0
TPM4-014 ENSP00000466106 ENST00000588483	K7ELJ3 [Direct mapping] Tropomyosin alpha-4 chain Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		16 aa 2 kDa	No	0
TPM4-015 ENSP00000466654 ENST00000592138	K7EMU5 [Direct mapping] Tropomyosin alpha-4 chain Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		102 aa 12 kDa	No	0
TPM4-019 ENSP00000468010 ENST00000592822	K7EQW8 [Direct mapping] Tropomyosin alpha-4 chain Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		59 aa 6.8 kDa	No	0

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