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AQP2

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GENERAL INFORMATION

Gene name

 AQP2

Gene description

 Aquaporin 2 (collecting duct)

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (EFO-21, HMC-1)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (EFO-21, HMC-1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 AQP2

Synonyms

Description

 Aquaporin 2 (collecting duct) (HGNC Symbol)

Entrez gene summary

 This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008]

Chromosome

 12

Cytoband

 q13.12

Chromosome location (bp)

 49950741 - 49958881

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167580 (version 83.38)

Entrez gene

 359

UniProt

 P41181 (UniProt - Evidence at protein level)

neXtProt

 NX_P41181

Antibodypedia

 AQP2 antibodies

PROTEIN BROWSER
AQP2-001
AQP2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AQP2-001
ENSP00000199280
ENST00000199280
P41181 [Direct mapping]
Aquaporin-2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0003091 [renal water homeostasis]
GO:0003097 [renal water transport]
GO:0005215 [transporter activity]
GO:0005372 [water transmembrane transporter activity]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006833 [water transport]
GO:0007588 [excretion]
GO:0009992 [cellular water homeostasis]
GO:0015168 [glycerol transmembrane transporter activity]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0030658 [transport vesicle membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0034220 [ion transmembrane transport]
GO:0042631 [cellular response to water deprivation]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071280 [cellular response to copper ion]
GO:0071288 [cellular response to mercury ion]
GO:0072205 [metanephric collecting duct development]
Show all
 271 aa
28.8 kDa 		No 7
AQP2-004
ENSP00000450022
ENST00000550862
F8VPL3 [Direct mapping]
Aquaporin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005215 [transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0009992 [cellular water homeostasis]
GO:0015254 [glycerol channel activity]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
Show all
 244 aa
26.1 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.