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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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AQP2
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

AQP2

Gene description

Aquaporin 2 (collecting duct)

Protein class

Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Group enriched (renal cancer, stomach cancer)
HPA (cell line):Cell line enhanced (EFO-21, HMC-1)
HPA (normal tissue):Group enriched (kidney, seminal vesicle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective membranous expression in subsets of renal tubules.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA046834
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Group enriched (renal cancer, stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY

HPA046834

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues were negative.

GENE INFORMATION

Gene name

AQP2

Synonyms

Description

Aquaporin 2 (collecting duct) (HGNC Symbol)

Entrez gene summary

This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008]

Chromosome

12

Cytoband

q13.12

Chromosome location (bp)

49950741 - 49958881

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167580 (version 83.38)

Entrez gene

359

UniProt

P41181 (UniProt - Evidence at protein level)

neXtProt

NX_P41181

Antibodypedia

AQP2 antibodies

PROTEIN BROWSER

AQP2-001
AQP2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AQP2-001
ENSP00000199280
ENST00000199280
P41181 [Direct mapping]
Aquaporin-2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0003091 [renal water homeostasis]
GO:0003097 [renal water transport]
GO:0005215 [transporter activity]
GO:0005372 [water transmembrane transporter activity]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006833 [water transport]
GO:0007588 [excretion]
GO:0009992 [cellular water homeostasis]
GO:0015168 [glycerol transmembrane transporter activity]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0030658 [transport vesicle membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0034220 [ion transmembrane transport]
GO:0042631 [cellular response to water deprivation]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071280 [cellular response to copper ion]
GO:0071288 [cellular response to mercury ion]
GO:0072205 [metanephric collecting duct development]
Show all
271 aa
28.8 kDa
No 7
AQP2-004
ENSP00000450022
ENST00000550862
F8VPL3 [Direct mapping]
Aquaporin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005215 [transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0009992 [cellular water homeostasis]
GO:0015254 [glycerol channel activity]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
Show all
244 aa
26.1 kDa
No 6

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