Expression of CDC42EP5 in cancer - Summary

GENERAL INFORMATION
Gene name	CDC42EP5
Gene description	CDC42 effector protein (Rho GTPase binding) 5
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (colon, prostate)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in glandular cells of the gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA043449
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA043449

GENE INFORMATION
Gene name	CDC42EP5 (HGNC Symbol)
Synonyms	Borg3, CEP5
Description	CDC42 effector protein (Rho GTPase binding) 5 (HGNC Symbol)
Entrez gene summary	Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013]
Chromosome	19
Cytoband	q13.42
Chromosome location (bp)	54465026 - 54473264
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167617 (version 83.38)
Entrez gene	148170
UniProt	Q6NZY7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6NZY7
Antibodypedia	CDC42EP5 antibodies

PROTEIN BROWSER

CDC42EP5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDC42EP5-001 ENSP00000301200 ENST00000301200	Q6NZY7 [Direct mapping] Cdc42 effector protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0007254 [JNK cascade] GO:0007266 [Rho protein signal transduction] GO:0008360 [regulation of cell shape] GO:0012505 [endomembrane system] GO:0016020 [membrane] GO:0017049 [GTP-Rho binding] GO:0030838 [positive regulation of actin filament polymerization] GO:0031274 [positive regulation of pseudopodium assembly] GO:0043547 [positive regulation of GTPase activity] Show all	148 aa 15.2 kDa	No	0