Expression of PSCA in cancer - Summary - The Human Protein Atlas

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PSCA

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PSCA
Gene description	Prostate stem cell antigen
Protein class	Cancer-related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (urothelial cancer)
HPA (cell line):	Cell line enhanced (CAPAN-2, HeLa, RT4)
HPA (normal tissue):	Tissue enhanced (stomach, urinary bladder)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in stomach and renal tubules of kidney.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA056418
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (urothelial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA056418

GENE INFORMATION
Gene name	PSCA
Synonyms
Description	Prostate stem cell antigen (HGNC Symbol)
Entrez gene summary	This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	142670308 - 142682724
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167653 (version 83.38)
Entrez gene	8000
UniProt	O43653 (UniProt - Evidence at protein level)
neXtProt	NX_O43653
Antibodypedia	PSCA antibodies

PROTEIN BROWSER

PSCA-001	PSCA-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PSCA-001 ENSP00000301258 ENST00000301258	O43653 [Direct mapping] Prostate stem cell antigen D3DWI6 [Target identity:100%; Query identity:100%] Prostate stem cell antigen, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] Show all	114 aa 12 kDa	No	1
PSCA-002 ENSP00000426508 ENST00000513264	H0YAA6 [Direct mapping] Prostate stem cell antigen Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		54 aa 6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.