Fields »
ABOUT
HELP
BLOG
PSCA

GENERAL INFORMATION

Gene name

 PSCA

Gene description

 Prostate stem cell antigen

Protein class

 Cancer-related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (stomach, urinary bladder)
GTEx:Group enriched (stomach, urinary bladder)
FANTOM5:Tissue enhanced (esophagus, urinary bladder)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in stomach and renal tubules of kidney.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA056418
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (stomach, urinary bladder)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (stomach, urinary bladder)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, urinary bladder)

GENE INFORMATION

Gene name

 PSCA

Synonyms

Description

 Prostate stem cell antigen (HGNC Symbol)

Entrez gene summary

 This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Chromosome

 8

Cytoband

 q24.3

Chromosome location (bp)

 142670308 - 142682724

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167653 (version 83.38)

Entrez gene

 8000

UniProt

 O43653 (UniProt - Evidence at protein level)

neXtProt

 NX_O43653

Antibodypedia

 PSCA antibodies

PROTEIN BROWSER
PSCA-001
PSCA-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PSCA-001
ENSP00000301258
ENST00000301258
O43653 [Direct mapping]
Prostate stem cell antigen
D3DWI6 [Target identity:100%; Query identity:100%]
Prostate stem cell antigen, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005886 [plasma membrane]
GO:0031225 [anchored component of membrane]
GO:0070062 [extracellular exosome]
Show all
 114 aa
12 kDa 		No 1
PSCA-002
ENSP00000426508
ENST00000513264
H0YAA6 [Direct mapping]
Prostate stem cell antigen
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 54 aa
6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.