Cell atlas - PLIN4 - The Human Protein Atlas

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PLIN4

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Lipid droplets
	Plasma membrane
	Vesicles

Human cell
	Cytosol
	Plasma Membrane
	Vesicles

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GENERAL INFORMATION
Gene name	PLIN4
Gene description	Perilipin 4
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane, cytosol & lipid droplets. In addition localized to vesicles.
RNA cell category	Cell line enhanced (RT4, BEWO, PC-3)
Protein evidence	Evidence at protein level
Main location	Localized to the Lipid droplets (supported), Plasma membrane (supported), Cytosol (supported)
Additional location	In addition localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA044682 , HPA054657
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RT4, BEWO, PC-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane, cytosol & lipid droplets. In addition localized to vesicles.

Main location

Lipid droplets (supported), Plasma membrane (supported), Cytosol (supported)

Additional location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA044682	A-431	No staining
HPA044682	RT4	Lipid droplets
		Plasma membrane
		Cytosol
HPA044682	U-2 OS	No staining
HPA054657	PC-3	Vesicles
		Plasma membrane
		Cytosol
HPA054657	RT4	Lipid droplets
HPA054657	RT4	Cytosol
HPA054657	U-2 OS	Vesicles

GENE INFORMATION
Gene name	PLIN4 (HGNC Symbol)
Synonyms	KIAA1881, S3-12
Description	Perilipin 4 (HGNC Symbol)
Entrez gene summary	Members of the perilipin family, such as PLIN4, coat intracellular lipid storage droplets (Wolins et al., 2003 [PubMed 12840023]).[supplied by OMIM, Feb 2010]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	4502180 - 4518465
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167676 (version 83.38)
Entrez gene	729359
UniProt	Q96Q06 (UniProt - Evidence at protein level)
neXtProt	NX_Q96Q06
Antibodypedia	PLIN4 antibodies

PROTEIN BROWSER

PLIN4-001	PLIN4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLIN4-001 ENSP00000488481 ENST00000633942		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		1372 aa 136 kDa	No	0
PLIN4-201 ENSP00000301286 ENST00000301286	Q96Q06 [Direct mapping] Perilipin-4 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005811 [lipid particle] GO:0005886 [plasma membrane] Show all	1357 aa 134.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.