Expression of SLC43A2 in cancer - Summary - The Human Protein Atlas

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SLC43A2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC43A2
Gene description	Solute carrier family 43 (amino acid system L transporter), member 2
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (CACO-2)
HPA (normal tissue):	Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in a few tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA021564
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and renal cancer (favourable).
Pancreatic cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021564

GENE INFORMATION
Gene name	SLC43A2 (HGNC Symbol)
Synonyms	MGC34680
Description	Solute carrier family 43 (amino acid system L transporter), member 2 (HGNC Symbol)
Entrez gene summary	System L amino acid transporters, such as SLC43A2, mediate sodium-independent transport of bulky neutral amino acids across cell membranes (Bodoy et al., 2005 [PubMed 15659399]).[supplied by OMIM, Mar 2008]
Chromosome	17
Cytoband	p13.3
Chromosome location (bp)	1569267 - 1628886
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167703 (version 83.38)
Entrez gene	124935
UniProt	Q8N370 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N370
Antibodypedia	SLC43A2 antibodies

PROTEIN BROWSER

SLC43A2-001	SLC43A2-004	SLC43A2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC43A2-001 ENSP00000301335 ENST00000301335	Q8N370 [Direct mapping] Large neutral amino acids transporter small subunit 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0015175 [neutral amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015804 [neutral amino acid transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:1902475 [L-alpha-amino acid transmembrane transport] Show all	569 aa 62.7 kDa	No	>9
SLC43A2-004 ENSP00000461382 ENST00000571650	Q8N370 [Direct mapping] Large neutral amino acids transporter small subunit 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0015175 [neutral amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015804 [neutral amino acid transport] GO:0015807 [L-amino acid transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:1902475 [L-alpha-amino acid transmembrane transport] Show all	573 aa 63.1 kDa	No	>9
SLC43A2-005 ENSP00000408284 ENST00000412517	Q8N370 [Direct mapping] Large neutral amino acids transporter small subunit 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0015175 [neutral amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015804 [neutral amino acid transport] GO:0055085 [transmembrane transport] GO:1902475 [L-alpha-amino acid transmembrane transport] Show all	432 aa 48 kDa	No	8

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.