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SERPINF2

GENERAL INFORMATION

Gene name

 SERPINF2

Gene description

 Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

Protein class

 Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enriched (Hep G2)
HPA (normal tissue):Tissue enhanced (epididymis, liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Positivity in plasma in several tissues. Cytoplasmic and membranous expression in most cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 2 antibodies.
HPA001885 , CAB024863
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001885
CAB024863

GENE INFORMATION

Gene name

 SERPINF2 (HGNC Symbol)

Synonyms

 A2AP, AAP, ALPHA-2-PI, API, PLI

Description

 Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

 17

Cytoband

 p13.3

Chromosome location (bp)

 1742836 - 1755268

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167711 (version 83.38)

Entrez gene

 5345

UniProt

 P08697 (UniProt - Evidence at protein level)

neXtProt

 NX_P08697

Antibodypedia

 SERPINF2 antibodies

PROTEIN BROWSER
SERPINF2-001
SERPINF2-002
SERPINF2-003
SERPINF2-004
SERPINF2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SERPINF2-001
ENSP00000371493
ENST00000382061
P08697 [Direct mapping]
Alpha-2-antiplasmin
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0002034 [regulation of blood vessel size by renin-angiotensin]
GO:0002576 [platelet degranulation]
GO:0004866 [endopeptidase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0006953 [acute-phase response]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0010757 [negative regulation of plasminogen activation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0030168 [platelet activation]
GO:0030199 [collagen fibril organization]
GO:0031093 [platelet alpha granule lumen]
GO:0032967 [positive regulation of collagen biosynthetic process]
GO:0042730 [fibrinolysis]
GO:0042803 [protein homodimerization activity]
GO:0045597 [positive regulation of cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0048514 [blood vessel morphogenesis]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051918 [negative regulation of fibrinolysis]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071636 [positive regulation of transforming growth factor beta production]
GO:0072562 [blood microparticle]
GO:2000049 [positive regulation of cell-cell adhesion mediated by cadherin]
Show all
 491 aa
54.6 kDa 		Yes 0
SERPINF2-002
ENSP00000402286
ENST00000453066
C9JMH6 [Direct mapping]
Alpha-2-antiplasmin
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0010951 [negative regulation of endopeptidase activity]
Show all
 255 aa
27.8 kDa 		Yes 0
SERPINF2-003
ENSP00000402056
ENST00000453723
C9JPV4 [Direct mapping]
Alpha-2-antiplasmin
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0010951 [negative regulation of endopeptidase activity]
Show all
 264 aa
29.5 kDa 		Yes 0
SERPINF2-004
ENSP00000403877
ENST00000450523
P08697 [Direct mapping]
Alpha-2-antiplasmin
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0002034 [regulation of blood vessel size by renin-angiotensin]
GO:0002576 [platelet degranulation]
GO:0004866 [endopeptidase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0006953 [acute-phase response]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0010757 [negative regulation of plasminogen activation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0030168 [platelet activation]
GO:0030199 [collagen fibril organization]
GO:0031093 [platelet alpha granule lumen]
GO:0032967 [positive regulation of collagen biosynthetic process]
GO:0042730 [fibrinolysis]
GO:0042803 [protein homodimerization activity]
GO:0045597 [positive regulation of cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0048514 [blood vessel morphogenesis]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051918 [negative regulation of fibrinolysis]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071636 [positive regulation of transforming growth factor beta production]
GO:0072562 [blood microparticle]
GO:2000049 [positive regulation of cell-cell adhesion mediated by cadherin]
Show all
 427 aa
47.9 kDa 		Yes 0
SERPINF2-201
ENSP00000321853
ENST00000324015
P08697 [Direct mapping]
Alpha-2-antiplasmin
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0002034 [regulation of blood vessel size by renin-angiotensin]
GO:0002576 [platelet degranulation]
GO:0004866 [endopeptidase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0006953 [acute-phase response]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0010033 [response to organic substance]
GO:0010757 [negative regulation of plasminogen activation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0030168 [platelet activation]
GO:0030199 [collagen fibril organization]
GO:0031093 [platelet alpha granule lumen]
GO:0032967 [positive regulation of collagen biosynthetic process]
GO:0042730 [fibrinolysis]
GO:0042803 [protein homodimerization activity]
GO:0045597 [positive regulation of cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0048514 [blood vessel morphogenesis]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051918 [negative regulation of fibrinolysis]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071636 [positive regulation of transforming growth factor beta production]
GO:0072562 [blood microparticle]
GO:2000049 [positive regulation of cell-cell adhesion mediated by cadherin]
Show all
 491 aa
54.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.