Cell atlas - HSD11B1L - The Human Protein Atlas

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HSD11B1L

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	HSD11B1L
Gene description	Hydroxysteroid (11-beta) dehydrogenase 1-like
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles.
RNA cell category	Cell line enhanced (SH-SY5Y)
Protein evidence	Evidence at transcript level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA049078
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA049078	SK-MEL-30	Vesicles
	HPA049078	U-2 OS	Nucleoplasm
	HPA049078	U-2 OS	Vesicles

GENE INFORMATION
Gene name	HSD11B1L (HGNC Symbol)
Synonyms	SCDR10, SDR26C2
Description	Hydroxysteroid (11-beta) dehydrogenase 1-like (HGNC Symbol)
Entrez gene summary	This gene is a member of the hydroxysteroid dehydrogenase family. The encoded protein is similar to an enzyme that catalyzes the interconversion of inactive to active glucocorticoids (e.g. cortisone). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	5680604 - 5688523
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000167733 (version 83.38)
Entrez gene	374875
UniProt	Q7Z5J1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q7Z5J1
Antibodypedia	HSD11B1L antibodies

PROTEIN BROWSER

HSD11B1L-001	HSD11B1L-002	HSD11B1L-003	HSD11B1L-004	HSD11B1L-005	HSD11B1L-006	HSD11B1L-007	HSD11B1L-008	HSD11B1L-009	HSD11B1L-012	HSD11B1L-013	HSD11B1L-016	HSD11B1L-019	HSD11B1L-021	HSD11B1L-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HSD11B1L-001 ENSP00000340436 ENST00000339423	Q7Z5J1 [Direct mapping] Hydroxysteroid 11-beta-dehydrogenase 1-like protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	286 aa 30.8 kDa	Yes	0
HSD11B1L-002 ENSP00000407154 ENST00000423665	Q7Z5J1 [Direct mapping] Hydroxysteroid 11-beta-dehydrogenase 1-like protein Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	315 aa 34.3 kDa	Yes	0
HSD11B1L-003 ENSP00000301382 ENST00000301382	Q7Z5J1 [Direct mapping] Hydroxysteroid 11-beta-dehydrogenase 1-like protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	205 aa 22.3 kDa	Yes	0
HSD11B1L-004 ENSP00000463073 ENST00000577917	Q7Z5J1 [Direct mapping] Hydroxysteroid 11-beta-dehydrogenase 1-like protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	234 aa 25.8 kDa	Yes	0
HSD11B1L-005 ENSP00000398955 ENST00000411793	Q7Z5J1 [Direct mapping] Hydroxysteroid 11-beta-dehydrogenase 1-like protein Show all	Predicted intracellular proteins Show all	GO:0005576 [extracellular region] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	181 aa 20 kDa	No	0
HSD11B1L-006 ENSP00000462975 ENST00000581773	Q7Z5J1 [Direct mapping] Hydroxysteroid 11-beta-dehydrogenase 1-like protein Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	286 aa 30.8 kDa	Yes	0
HSD11B1L-007 ENSP00000463794 ENST00000581521	Q7Z5J1 [Direct mapping] Hydroxysteroid 11-beta-dehydrogenase 1-like protein Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	286 aa 30.8 kDa	Yes	0
HSD11B1L-008 ENSP00000464454 ENST00000581893	Q7Z5J1 [Direct mapping] Hydroxysteroid 11-beta-dehydrogenase 1-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0005576 [extracellular region] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	152 aa 16.5 kDa	No	0
HSD11B1L-009 ENSP00000462586 ENST00000583928	Q7Z5J1 [Direct mapping] Hydroxysteroid 11-beta-dehydrogenase 1-like protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0005576 [extracellular region] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	152 aa 16.5 kDa	No	0
HSD11B1L-012 ENSP00000343451 ENST00000342970	Q7Z5J1 [Direct mapping] Hydroxysteroid 11-beta-dehydrogenase 1-like protein Show all	Predicted intracellular proteins Show all	GO:0005576 [extracellular region] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	199 aa 21.5 kDa	No	0
HSD11B1L-013 ENSP00000409592 ENST00000422535	Q7Z5J1 [Direct mapping] Hydroxysteroid 11-beta-dehydrogenase 1-like protein Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	87 aa 9.5 kDa	Yes	0
HSD11B1L-016 ENSP00000464652 ENST00000577257	J3QSE6 [Direct mapping] Hydroxysteroid 11-beta-dehydrogenase 1-like protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	143 aa 15.4 kDa	Yes	0
HSD11B1L-019 ENSP00000463187 ENST00000579559	J3QKQ3 [Direct mapping] Hydroxysteroid 11-beta-dehydrogenase 1-like protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		189 aa 19.7 kDa	Yes	0
HSD11B1L-021 ENSP00000462921 ENST00000578046	J3KTC8 [Direct mapping] Hydroxysteroid 11-beta-dehydrogenase 1-like protein Show all	Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	135 aa 14.5 kDa	No	0
HSD11B1L-201 ENSP00000480443 ENST00000616276	A0A087WWR3 [Direct mapping] Hydroxysteroid 11-beta-dehydrogenase 1-like protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	333 aa 35.9 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.