Cell atlas - GGT6 - The Human Protein Atlas

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GGT6

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	GGT6
Gene description	Gamma-glutamyltransferase 6
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (T-47d, RT4, SK-BR-3)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (T-47d, RT4, SK-BR-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	GGT6 (HGNC Symbol)
Synonyms	FLJ90165
Description	Gamma-glutamyltransferase 6 (HGNC Symbol)
Entrez gene summary	GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	4556927 - 4560818
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167741 (version 83.38)
Entrez gene	124975
UniProt	Q6P531 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6P531
Antibodypedia	GGT6 antibodies

PROTEIN BROWSER

GGT6-001	GGT6-002	GGT6-003	GGT6-004	GGT6-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GGT6-001 ENSP00000301395 ENST00000301395	Q6P531 [Direct mapping] Gamma-glutamyltransferase 6 Gamma-glutamyltransferase 6 heavy chain Gamma-glutamyltransferase 6 light chain Show all	Enzymes ENZYME proteins Transferases Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006508 [proteolysis] GO:0006749 [glutathione metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0016021 [integral component of membrane] GO:0019370 [leukotriene biosynthetic process] GO:0031362 [anchored component of external side of plasma membrane] GO:0036374 [glutathione hydrolase activity] GO:0070062 [extracellular exosome] Show all	461 aa 47.5 kDa	No	1
GGT6-002 ENSP00000370962 ENST00000381550	J3KPJ0 [Direct mapping] Gamma-glutamyltransferase 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	499 aa 51.1 kDa	No	2
GGT6-003 ENSP00000458307 ENST00000574154	Q6P531 [Direct mapping] Gamma-glutamyltransferase 6 Gamma-glutamyltransferase 6 heavy chain Gamma-glutamyltransferase 6 light chain Show all	Enzymes ENZYME proteins Transferases Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006508 [proteolysis] GO:0006749 [glutathione metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0016021 [integral component of membrane] GO:0019370 [leukotriene biosynthetic process] GO:0031362 [anchored component of external side of plasma membrane] GO:0036374 [glutathione hydrolase activity] GO:0070062 [extracellular exosome] Show all	493 aa 50.5 kDa	No	2
GGT6-004 ENSP00000461230 ENST00000573591	B4DPG6 [Direct mapping] Gamma-glutamyltransferase 6; cDNA FLJ51026 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	345 aa 35.2 kDa	No	0
GGT6-006 ENSP00000459662 ENST00000574584	I3L2G6 [Direct mapping] Gamma-glutamyltransferase 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	180 aa 19 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.