Tissue expression of GGT6 - Summary - The Human Protein Atlas

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GGT6

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GGT6
Gene description	Gamma-glutamyltransferase 6
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Tissue enhanced (salivary gland, small intestine)

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA023362 , HPA027213
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (salivary gland, small intestine)

GENE INFORMATION
Gene name	GGT6 (HGNC Symbol)
Synonyms	FLJ90165
Description	Gamma-glutamyltransferase 6 (HGNC Symbol)
Entrez gene summary	GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	4556927 - 4560818
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167741 (version 83.38)
Entrez gene	124975
UniProt	Q6P531 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6P531
Antibodypedia	GGT6 antibodies

PROTEIN BROWSER

GGT6-001	GGT6-002	GGT6-003	GGT6-004	GGT6-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GGT6-001 ENSP00000301395 ENST00000301395	Q6P531 [Direct mapping] Gamma-glutamyltransferase 6 Gamma-glutamyltransferase 6 heavy chain Gamma-glutamyltransferase 6 light chain Show all	Enzymes ENZYME proteins Transferases Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006508 [proteolysis] GO:0006749 [glutathione metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0016021 [integral component of membrane] GO:0019370 [leukotriene biosynthetic process] GO:0031362 [anchored component of external side of plasma membrane] GO:0036374 [glutathione hydrolase activity] GO:0070062 [extracellular exosome] Show all	461 aa 47.5 kDa	No	1
GGT6-002 ENSP00000370962 ENST00000381550	J3KPJ0 [Direct mapping] Gamma-glutamyltransferase 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	499 aa 51.1 kDa	No	2
GGT6-003 ENSP00000458307 ENST00000574154	Q6P531 [Direct mapping] Gamma-glutamyltransferase 6 Gamma-glutamyltransferase 6 heavy chain Gamma-glutamyltransferase 6 light chain Show all	Enzymes ENZYME proteins Transferases Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006508 [proteolysis] GO:0006749 [glutathione metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0016021 [integral component of membrane] GO:0019370 [leukotriene biosynthetic process] GO:0031362 [anchored component of external side of plasma membrane] GO:0036374 [glutathione hydrolase activity] GO:0070062 [extracellular exosome] Show all	493 aa 50.5 kDa	No	2
GGT6-004 ENSP00000461230 ENST00000573591	B4DPG6 [Direct mapping] Gamma-glutamyltransferase 6; cDNA FLJ51026 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	345 aa 35.2 kDa	No	0
GGT6-006 ENSP00000459662 ENST00000574584	I3L2G6 [Direct mapping] Gamma-glutamyltransferase 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	180 aa 19 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.