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KRT80

GENERAL INFORMATION

Gene name

 KRT80

Gene description

 Keratin 80, type II

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skin)
GTEx:Tissue enriched (skin)
FANTOM5:Tissue enhanced (salivary gland, tonsil)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (salivary gland, tonsil)

GENE INFORMATION

Gene name

 KRT80 (HGNC Symbol)

Synonyms

 KB20

Description

 Keratin 80, type II (HGNC Symbol)

Entrez gene summary

 Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 52168996 - 52192000

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167767 (version 83.38)

Entrez gene

 144501

UniProt

 Q6KB66 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6KB66

Antibodypedia

 KRT80 antibodies

PROTEIN BROWSER
KRT80-001
KRT80-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT80-001
ENSP00000369361
ENST00000313234
Q6KB66 [Direct mapping]
Keratin, type II cytoskeletal 80
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005882 [intermediate filament]
GO:0045095 [keratin filament]
Show all
 422 aa
47.2 kDa 		No 0
KRT80-002
ENSP00000378292
ENST00000394815
Q6KB66 [Direct mapping]
Keratin, type II cytoskeletal 80
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005882 [intermediate filament]
GO:0045095 [keratin filament]
Show all
 452 aa
50.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.