Expression of CD300C in cancer - Summary - The Human Protein Atlas

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CD300C

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CD300C
Gene description	CD300c molecule
Protein class	CD markers Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HEL, HMC-1, U-937)
HPA (normal tissue):	Tissue enhanced (lung)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, including immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA014523
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PROGNOSTIC SUMMARY
Prognostic marker in testis cancer (unfavourable).
Testis cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014523

GENE INFORMATION
Gene name	CD300C (HGNC Symbol)
Synonyms	CMRF-35A, CMRF35, CMRF35A, IGSF16, LIR
Description	CD300c molecule (HGNC Symbol)
Entrez gene summary	The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).[supplied by OMIM, Mar 2008]
Chromosome	17
Cytoband	q25.1
Chromosome location (bp)	74541108 - 74546143
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000167850 (version 83.38)
Entrez gene	10871
UniProt	Q08708 (UniProt - Evidence at transcript level)
neXtProt	NX_Q08708
Antibodypedia	CD300C antibodies

PROTEIN BROWSER

CD300C-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD300C-001 ENSP00000329507 ENST00000330793	Q08708 [Direct mapping] CMRF35-like molecule 6 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0002376 [immune system process] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006968 [cellular defense response] GO:0007165 [signal transduction] GO:0050776 [regulation of immune response] Show all	224 aa 24.8 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.