Cell atlas - MGAT5B - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MGAT5B

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Mitotic spindle
	Nucleoplasm

Human cell
	Microtubules
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	MGAT5B
Gene description	Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the mitotic spindle.
RNA cell category	Cell line enhanced (A549, U-2 OS, SCLC-21H, U-138 MG)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Mitotic spindle (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA011082
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A549, U-2 OS, SCLC-21H, U-138 MG) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the mitotic spindle.

Main location

Nucleoplasm (approved)

Additional location

Mitotic spindle (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA011082	A549	Nucleoplasm	Intensity
	HPA011082	U-2 OS	Nucleoplasm
	HPA011082	U-2 OS	Mitotic spindle	Intensity	Intensity

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Mitotic spindle, Nucleoplasm

GENE INFORMATION
Gene name	MGAT5B (HGNC Symbol)
Synonyms	FLJ25132, GnT-IX, GnT-VB
Description	Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B (HGNC Symbol)
Entrez gene summary	The MGAT5B gene encodes a beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.155) that functions in the synthesis of complex cell surface N-glycans (Kaneko et al., 2003 [PubMed 14623122]).[supplied by OMIM, Nov 2008]
Chromosome	17
Cytoband	q25.2
Chromosome location (bp)	76868456 - 76950393
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167889 (version 83.38)
Entrez gene	146664
UniProt	Q3V5L5 (UniProt - Evidence at protein level)
neXtProt	NX_Q3V5L5
Antibodypedia	MGAT5B antibodies

PROTEIN BROWSER

MGAT5B-001	MGAT5B-002	MGAT5B-003	MGAT5B-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MGAT5B-001 ENSP00000301618 ENST00000301618	Q3V5L5 [Direct mapping] Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0030144 [alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity] GO:0046872 [metal ion binding] Show all	790 aa 89.3 kDa	No	0
MGAT5B-002 ENSP00000391227 ENST00000428789	Q3V5L5 [Direct mapping] Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0006487 [protein N-linked glycosylation] GO:0016021 [integral component of membrane] GO:0030144 [alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity] GO:0046872 [metal ion binding] Show all	801 aa 90.6 kDa	No	1
MGAT5B-003 ENSP00000457614 ENST00000565675	H3BR20 [Direct mapping] Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0006487 [protein N-linked glycosylation] GO:0016021 [integral component of membrane] GO:0030144 [alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity] Show all	110 aa 12.3 kDa	No	0
MGAT5B-010 ENSP00000456037 ENST00000569840	Q3V5L5 [Direct mapping] Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0030144 [alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity] GO:0046872 [metal ion binding] Show all	792 aa 89.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.