Expression of MGAT5B in cancer - Summary - The Human Protein Atlas

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MGAT5B

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	MGAT5B
Gene description	Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, melanoma, testis cancer)
HPA (cell line):	Cell line enhanced (A549, SCLC-21H, U-138 MG, U-2 OS)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, melanoma, testis cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	MGAT5B (HGNC Symbol)
Synonyms	FLJ25132, GnT-IX, GnT-VB
Description	Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B (HGNC Symbol)
Entrez gene summary	The MGAT5B gene encodes a beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.155) that functions in the synthesis of complex cell surface N-glycans (Kaneko et al., 2003 [PubMed 14623122]).[supplied by OMIM, Nov 2008]
Chromosome	17
Cytoband	q25.2
Chromosome location (bp)	76868456 - 76950393
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167889 (version 83.38)
Entrez gene	146664
UniProt	Q3V5L5 (UniProt - Evidence at protein level)
neXtProt	NX_Q3V5L5
Antibodypedia	MGAT5B antibodies

PROTEIN BROWSER

MGAT5B-001	MGAT5B-002	MGAT5B-003	MGAT5B-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MGAT5B-001 ENSP00000301618 ENST00000301618	Q3V5L5 [Direct mapping] Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0030144 [alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity] GO:0046872 [metal ion binding] Show all	790 aa 89.3 kDa	No	0
MGAT5B-002 ENSP00000391227 ENST00000428789	Q3V5L5 [Direct mapping] Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0006487 [protein N-linked glycosylation] GO:0016021 [integral component of membrane] GO:0030144 [alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity] GO:0046872 [metal ion binding] Show all	801 aa 90.6 kDa	No	1
MGAT5B-003 ENSP00000457614 ENST00000565675	H3BR20 [Direct mapping] Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0006487 [protein N-linked glycosylation] GO:0016021 [integral component of membrane] GO:0030144 [alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity] Show all	110 aa 12.3 kDa	No	0
MGAT5B-010 ENSP00000456037 ENST00000569840	Q3V5L5 [Direct mapping] Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0030144 [alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity] GO:0046872 [metal ion binding] Show all	792 aa 89.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.