Cell atlas - TMC8 - The Human Protein Atlas

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TMC8

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	TMC8
Gene description	Transmembrane channel-like 8
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Cell line enhanced (HMC-1, Karpas-707, HL-60, RPMI-8226)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA047387
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1, Karpas-707, HL-60, RPMI-8226) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA047387	HaCaT	Golgi apparatus
	HPA047387	MCF7	Golgi apparatus

GENE INFORMATION
Gene name	TMC8 (HGNC Symbol)
Synonyms	EVER2, EVIN2
Description	Transmembrane channel-like 8 (HGNC Symbol)
Entrez gene summary	Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	78130770 - 78142968
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167895 (version 83.38)
Entrez gene	147138
UniProt	Q8IU68 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IU68
Antibodypedia	TMC8 antibodies

PROTEIN BROWSER

TMC8-002	TMC8-003	TMC8-006	TMC8-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMC8-002 ENSP00000325561 ENST00000318430	Q8IU68 [Direct mapping] Transmembrane channel-like protein 8 A0A024R8N8 [Target identity:100%; Query identity:100%] Transmembrane channel-like protein Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006811 [ion transport] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0032091 [negative regulation of protein binding] GO:0032460 [negative regulation of protein oligomerization] GO:0055069 [zinc ion homeostasis] GO:0070062 [extracellular exosome] GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors] Show all	726 aa 81.6 kDa	No	9
TMC8-003 ENSP00000467482 ENST00000589691	Q8IU68 [Direct mapping] Transmembrane channel-like protein 8 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006811 [ion transport] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0032091 [negative regulation of protein binding] GO:0032460 [negative regulation of protein oligomerization] GO:0055069 [zinc ion homeostasis] GO:0070062 [extracellular exosome] GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors] Show all	503 aa 56.1 kDa	No	7
TMC8-006 ENSP00000465049 ENST00000590799	K7EJ72 [Direct mapping] Transmembrane channel-like protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		196 aa 21.9 kDa	No	0
TMC8-012 ENSP00000467460 ENST00000590426		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		2 aa 0.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.