Expression of TMC8 in cancer - Summary - The Human Protein Atlas

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TMC8

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMC8
Gene description	Transmembrane channel-like 8
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HL-60, HMC-1, Karpas-707, RPMI-8226)
HPA (normal tissue):	Tissue enhanced (lymph node, spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA054429
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), cervical cancer (favourable) and head and neck cancer (favourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA054429

GENE INFORMATION
Gene name	TMC8 (HGNC Symbol)
Synonyms	EVER2, EVIN2
Description	Transmembrane channel-like 8 (HGNC Symbol)
Entrez gene summary	Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	78130770 - 78142968
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167895 (version 83.38)
Entrez gene	147138
UniProt	Q8IU68 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IU68
Antibodypedia	TMC8 antibodies

PROTEIN BROWSER

TMC8-002	TMC8-003	TMC8-006	TMC8-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMC8-002 ENSP00000325561 ENST00000318430	Q8IU68 [Direct mapping] Transmembrane channel-like protein 8 A0A024R8N8 [Target identity:100%; Query identity:100%] Transmembrane channel-like protein Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006811 [ion transport] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0032091 [negative regulation of protein binding] GO:0032460 [negative regulation of protein oligomerization] GO:0055069 [zinc ion homeostasis] GO:0070062 [extracellular exosome] GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors] Show all	726 aa 81.6 kDa	No	9
TMC8-003 ENSP00000467482 ENST00000589691	Q8IU68 [Direct mapping] Transmembrane channel-like protein 8 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006811 [ion transport] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0032091 [negative regulation of protein binding] GO:0032460 [negative regulation of protein oligomerization] GO:0055069 [zinc ion homeostasis] GO:0070062 [extracellular exosome] GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors] Show all	503 aa 56.1 kDa	No	7
TMC8-006 ENSP00000465049 ENST00000590799	K7EJ72 [Direct mapping] Transmembrane channel-like protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		196 aa 21.9 kDa	No	0
TMC8-012 ENSP00000467460 ENST00000590426		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		2 aa 0.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.