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ECI1

GENERAL INFORMATION

Gene name

 ECI1

Gene description

 Enoyl-CoA delta isomerase 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA041746 , HPA043227
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), cervical cancer (favourable) and liver cancer (favourable).
Renal cancer p<0.001
Cervical cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA041746
HPA043227

GENE INFORMATION

Gene name

 ECI1 (HGNC Symbol)

Synonyms

 DCI

Description

 Enoyl-CoA delta isomerase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 2239395 - 2252300

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167969 (version 83.38)

Entrez gene

 1632

UniProt

 P42126 (UniProt - Evidence at protein level)

neXtProt

 NX_P42126

Antibodypedia

 ECI1 antibodies

PROTEIN BROWSER
ECI1-001
ECI1-002
ECI1-004
ECI1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ECI1-001
ENSP00000301729
ENST00000301729
P42126 [Direct mapping]
Enoyl-CoA delta isomerase 1, mitochondrial
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Enzymes
   ENZYME proteins
   Isomerase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0004165 [dodecenoyl-CoA delta-isomerase activity]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0006635 [fatty acid beta-oxidation]
GO:0008152 [metabolic process]
GO:0016860 [intramolecular oxidoreductase activity]
GO:0042802 [identical protein binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 302 aa
32.8 kDa 		No 0
ECI1-002
ENSP00000456319
ENST00000562238
P42126 [Direct mapping]
Enoyl-CoA delta isomerase 1, mitochondrial
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Enzymes
   ENZYME proteins
   Isomerase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004165 [dodecenoyl-CoA delta-isomerase activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006635 [fatty acid beta-oxidation]
GO:0008152 [metabolic process]
GO:0016860 [intramolecular oxidoreductase activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 285 aa
30.9 kDa 		No 0
ECI1-004
ENSP00000457900
ENST00000570258
Q96DC0 [Direct mapping]
DCI protein; Dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme A isomerase), isoform CRA_a; Enoyl-CoA delta isomerase 1, mitochondrial
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
GO:0016853 [isomerase activity]
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 243 aa
27 kDa 		No 0
ECI1-005
ENSP00000456565
ENST00000566379
H3BS70 [Direct mapping]
Enoyl-CoA delta isomerase 1, mitochondrial
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
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 224 aa
24.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.