Expression of SRRM2 in cancer - Summary - The Human Protein Atlas

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SRRM2

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SRRM2
Gene description	Serine/arginine repetitive matrix 2
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA041411
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and head and neck cancer (favourable).
Renal cancer p<0.001 Liver cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041411

GENE INFORMATION
Gene name	SRRM2 (HGNC Symbol)
Synonyms	Cwc21, KIAA0324, SRL300, SRm300
Description	Serine/arginine repetitive matrix 2 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	2752329 - 2772538
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167978 (version 83.38)
Entrez gene	23524
UniProt	Q9UQ35 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UQ35
Antibodypedia	SRRM2 antibodies

PROTEIN BROWSER

SRRM2-001	SRRM2-003	SRRM2-006	SRRM2-007	SRRM2-012	SRRM2-013	SRRM2-028	SRRM2-032	SRRM2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SRRM2-001 ENSP00000301740 ENST00000301740	Q9UQ35 [Direct mapping] Serine/arginine repetitive matrix protein 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0015030 [Cajal body] GO:0016607 [nuclear speck] GO:0044822 [poly(A) RNA binding] GO:0047485 [protein N-terminus binding] GO:0070742 [C2H2 zinc finger domain binding] GO:0071013 [catalytic step 2 spliceosome] Show all	2752 aa 299.6 kDa	No	0
SRRM2-003 ENSP00000461181 ENST00000576924	I3L4D8 [Direct mapping] Serine/arginine repetitive matrix protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1018 aa 113.7 kDa	No	0
SRRM2-006 ENSP00000458870 ENST00000575009	I3L1I8 [Direct mapping] Serine/arginine repetitive matrix protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		297 aa 32.6 kDa	No	0
SRRM2-007 ENSP00000458647 ENST00000571378	I3L182 [Direct mapping] Serine/arginine repetitive matrix protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	895 aa 99.7 kDa	No	0
SRRM2-012 ENSP00000458230 ENST00000574340	I3L0N7 [Direct mapping] Serine/arginine repetitive matrix protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		115 aa 13.4 kDa	No	0
SRRM2-013 ENSP00000484503 ENST00000570971	A0A087X1W1 [Direct mapping] Serine/arginine repetitive matrix protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		251 aa 27.9 kDa	No	0
SRRM2-028 ENSP00000458718 ENST00000576415	I3L1C0 [Direct mapping] Serine/arginine repetitive matrix protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		94 aa 10.5 kDa	No	0
SRRM2-032 ENSP00000459157 ENST00000570539	I3L1W5 [Direct mapping] Serine/arginine repetitive matrix protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		41 aa 4.5 kDa	No	0
SRRM2-201 ENSP00000487247 ENST00000630499	Q9UQ35 [Direct mapping] Serine/arginine repetitive matrix protein 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0005654 [nucleoplasm] GO:0015030 [Cajal body] GO:0016607 [nuclear speck] GO:0044822 [poly(A) RNA binding] GO:0047485 [protein N-terminus binding] GO:0070742 [C2H2 zinc finger domain binding] GO:0071013 [catalytic step 2 spliceosome] Show all	311 aa 34.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.