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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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FADD
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

FADD

Gene description

Fas (TNFRSF6)-associated via death domain

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Low cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA001464 , CAB010209
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PROGNOSTIC SUMMARY

Prognostic marker in lung cancer (unfavourable), head and neck cancer (unfavourable), thyroid cancer (favourable) and cervical cancer (unfavourable).
Lung cancer p<0.001
Head and neck cancer p<0.001
Thyroid cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA001464
CAB010209

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cases of colorectal, breast, ovarian, urothelial, gastric, pancreatic, liver cancers and melanomas showed weak to moderate cytoplasmic positivity. Remaining cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

The majority of cancer cells showed weak to moderate cytoplasmic positivity. Nucleolar staining was observed in several cases. A few breast cancers were strongly stained.

GENE INFORMATION

Gene name

FADD (HGNC Symbol)

Synonyms

GIG3, MORT1

Description

Fas (TNFRSF6)-associated via death domain (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q13.3

Chromosome location (bp)

70203163 - 70207390

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168040 (version 83.38)

Entrez gene

8772

UniProt

Q13158 (UniProt - Evidence at protein level)

neXtProt

NX_Q13158

Antibodypedia

FADD antibodies

PROTEIN BROWSER

FADD-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FADD-001
ENSP00000301838
ENST00000301838
Q13158 [Direct mapping]
FAS-associated death domain protein
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001916 [positive regulation of T cell mediated cytotoxicity]
GO:0002020 [protease binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0002821 [positive regulation of adaptive immune response]
GO:0005123 [death receptor binding]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0031264 [death-inducing signaling complex]
GO:0031265 [CD95 death-inducing signaling complex]
GO:0032403 [protein complex binding]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0032813 [tumor necrosis factor receptor superfamily binding]
GO:0033077 [T cell differentiation in thymus]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035877 [death effector domain binding]
GO:0036462 [TRAIL-activated apoptotic signaling pathway]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043005 [neuron projection]
GO:0043029 [T cell homeostasis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043234 [protein complex]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045862 [positive regulation of proteolysis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048535 [lymph node development]
GO:0048536 [spleen development]
GO:0048538 [thymus development]
GO:0051291 [protein heterooligomerization]
GO:0051607 [defense response to virus]
GO:0060340 [positive regulation of type I interferon-mediated signaling pathway]
GO:0060546 [negative regulation of necroptotic process]
GO:0070236 [negative regulation of activation-induced cell death of T cells]
GO:0070266 [necroptotic process]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071550 [death-inducing signaling complex assembly]
GO:0097049 [motor neuron apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097202 [activation of cysteine-type endopeptidase activity]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097342 [ripoptosome]
GO:0097527 [necroptotic signaling pathway]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902043 [positive regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2000454 [positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
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208 aa
23.3 kDa
No 0

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