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Fas (TNFRSF6)-associated via death domain (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
Q13158 [Direct mapping] FAS-associated death domain protein
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Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001916 [positive regulation of T cell mediated cytotoxicity] GO:0002020 [protease binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0002821 [positive regulation of adaptive immune response] GO:0005123 [death receptor binding] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0010939 [regulation of necrotic cell death] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0031264 [death-inducing signaling complex] GO:0031265 [CD95 death-inducing signaling complex] GO:0032403 [protein complex binding] GO:0032729 [positive regulation of interferon-gamma production] GO:0032757 [positive regulation of interleukin-8 production] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0032813 [tumor necrosis factor receptor superfamily binding] GO:0033077 [T cell differentiation in thymus] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035877 [death effector domain binding] GO:0036462 [TRAIL-activated apoptotic signaling pathway] GO:0042104 [positive regulation of activated T cell proliferation] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043005 [neuron projection] GO:0043029 [T cell homeostasis] GO:0043065 [positive regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043234 [protein complex] GO:0044297 [cell body] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045651 [positive regulation of macrophage differentiation] GO:0045862 [positive regulation of proteolysis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048535 [lymph node development] GO:0048536 [spleen development] GO:0048538 [thymus development] GO:0051291 [protein heterooligomerization] GO:0051607 [defense response to virus] GO:0060340 [positive regulation of type I interferon-mediated signaling pathway] GO:0060546 [negative regulation of necroptotic process] GO:0070236 [negative regulation of activation-induced cell death of T cells] GO:0070266 [necroptotic process] GO:0071260 [cellular response to mechanical stimulus] GO:0071550 [death-inducing signaling complex assembly] GO:0097049 [motor neuron apoptotic process] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:0097202 [activation of cysteine-type endopeptidase activity] GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097300 [programmed necrotic cell death] GO:0097342 [ripoptosome] GO:0097527 [necroptotic signaling pathway] GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902043 [positive regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:2000454 [positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]