Expression of MAP4K2 in cancer - Summary

GENERAL INFORMATION
Gene name	MAP4K2
Gene description	Mitogen-activated protein kinase kinase kinase kinase 2
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression, including in lymph nodes and tonsil germinal centers.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA007330
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA007330

GENE INFORMATION
Gene name	MAP4K2 (HGNC Symbol)
Synonyms	BL44, GCK, RAB8IP
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	64784914 - 64803241
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168067 (version 83.38)
Entrez gene	5871
UniProt	Q12851 (UniProt - Evidence at protein level)
neXtProt	NX_Q12851
Antibodypedia	MAP4K2 antibodies

PROTEIN BROWSER

MAP4K2-001	MAP4K2-002	MAP4K2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAP4K2-001 ENSP00000294066 ENST00000294066	Q12851 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 2 A0A024R567 [Target identity:100%; Query identity:100%] Mitogen-activated protein kinase kinase kinase kinase Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0000185 [activation of MAPKKK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0006903 [vesicle targeting] GO:0006955 [immune response] GO:0007254 [JNK cascade] GO:0007257 [activation of JUN kinase activity] GO:0007346 [regulation of mitotic cell cycle] GO:0008349 [MAP kinase kinase kinase kinase activity] GO:0016323 [basolateral plasma membrane] GO:0031435 [mitogen-activated protein kinase kinase kinase binding] GO:0035556 [intracellular signal transduction] GO:0042981 [regulation of apoptotic process] GO:0045087 [innate immune response] GO:0046330 [positive regulation of JNK cascade] Show all	820 aa 91.6 kDa	No	0
MAP4K2-002 ENSP00000366567 ENST00000377350	Q12851 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 2 A0A0A6YYA7 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000185 [activation of MAPKKK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0006955 [immune response] GO:0007254 [JNK cascade] GO:0007257 [activation of JUN kinase activity] GO:0007346 [regulation of mitotic cell cycle] GO:0008349 [MAP kinase kinase kinase kinase activity] GO:0016323 [basolateral plasma membrane] GO:0031435 [mitogen-activated protein kinase kinase kinase binding] GO:0035556 [intracellular signal transduction] GO:0042981 [regulation of apoptotic process] GO:0045087 [innate immune response] GO:0046330 [positive regulation of JNK cascade] Show all	812 aa 90.8 kDa	No	0
MAP4K2-006 ENSP00000403563 ENST00000439069	C9JCU6 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000185 [activation of MAPKKK activity] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0008349 [MAP kinase kinase kinase kinase activity] GO:0042981 [regulation of apoptotic process] Show all	307 aa 34.8 kDa	No	0