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MAP4K2

GENERAL INFORMATION

Gene name

 MAP4K2

Gene description

 Mitogen-activated protein kinase kinase kinase kinase 2

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression, including in lymph nodes and tonsil germinal centers.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA007330
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Esophagus
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MAP4K2 (HGNC Symbol)

Synonyms

 BL44, GCK, RAB8IP

Description

 Mitogen-activated protein kinase kinase kinase kinase 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 64784914 - 64803241

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168067 (version 83.38)

Entrez gene

 5871

UniProt

 Q12851 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12851

Antibodypedia

 MAP4K2 antibodies

PROTEIN BROWSER
MAP4K2-001
MAP4K2-002
MAP4K2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAP4K2-001
ENSP00000294066
ENST00000294066
Q12851 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 2
A0A024R567 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase kinase kinase kinase
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000185 [activation of MAPKKK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006903 [vesicle targeting]
GO:0006955 [immune response]
GO:0007254 [JNK cascade]
GO:0007257 [activation of JUN kinase activity]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008349 [MAP kinase kinase kinase kinase activity]
GO:0016323 [basolateral plasma membrane]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0046330 [positive regulation of JNK cascade]
Show all
 820 aa
91.6 kDa 		No 0
MAP4K2-002
ENSP00000366567
ENST00000377350
Q12851 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 2
A0A0A6YYA7 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000185 [activation of MAPKKK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006955 [immune response]
GO:0007254 [JNK cascade]
GO:0007257 [activation of JUN kinase activity]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008349 [MAP kinase kinase kinase kinase activity]
GO:0016323 [basolateral plasma membrane]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0046330 [positive regulation of JNK cascade]
Show all
 812 aa
90.8 kDa 		No 0
MAP4K2-006
ENSP00000403563
ENST00000439069
C9JCU6 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000185 [activation of MAPKKK activity]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008349 [MAP kinase kinase kinase kinase activity]
GO:0042981 [regulation of apoptotic process]
Show all
 307 aa
34.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.