Cell atlas - COPS6 - The Human Protein Atlas

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COPS6

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	COPS6
Gene description	COP9 signalosome subunit 6
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA044315
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA044315	A-431	Nucleoplasm
	HPA044315	U-2 OS	Nucleoplasm
	HPA044315	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	COPS6 (HGNC Symbol)
Synonyms	CSN6, MOV34-34KD
Description	COP9 signalosome subunit 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	100088954 - 100092200
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168090 (version 83.38)
Entrez gene	10980
UniProt	Q7L5N1 (UniProt - Evidence at protein level)
neXtProt	NX_Q7L5N1
Antibodypedia	COPS6 antibodies

PROTEIN BROWSER

COPS6-001	COPS6-004	COPS6-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COPS6-001 ENSP00000304102 ENST00000303904	Q7L5N1 [Direct mapping] COP9 signalosome complex subunit 6 Show all	Enzymes Peptidases Metallopeptidases Phobius predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000715 [nucleotide-excision repair, DNA damage recognition] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0008180 [COP9 signalosome] GO:0010388 [cullin deneddylation] GO:0016032 [viral process] GO:0070062 [extracellular exosome] GO:0070911 [global genome nucleotide-excision repair] Show all	327 aa 36.2 kDa	Yes	0
COPS6-004 ENSP00000400617 ENST00000418625	E7EM64 [Direct mapping] COP9 signalosome complex subunit 6 Show all	Phobius predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] Show all	326 aa 36.1 kDa	Yes	0
COPS6-007 ENSP00000388865 ENST00000419210	C9JQK5 [Direct mapping] COP9 signalosome complex subunit 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		42 aa 4.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.