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COPS6

GENERAL INFORMATION

Gene name

 COPS6

Gene description

 COP9 signalosome subunit 6

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA044315
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA044315

GENE INFORMATION

Gene name

 COPS6 (HGNC Symbol)

Synonyms

 CSN6, MOV34-34KD

Description

 COP9 signalosome subunit 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 100088954 - 100092200

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168090 (version 83.38)

Entrez gene

 10980

UniProt

 Q7L5N1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7L5N1

Antibodypedia

 COPS6 antibodies

PROTEIN BROWSER
COPS6-001
COPS6-004
COPS6-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COPS6-001
ENSP00000304102
ENST00000303904
Q7L5N1 [Direct mapping]
COP9 signalosome complex subunit 6
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Enzymes
   Peptidases
   Metallopeptidases
   Phobius predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0008180 [COP9 signalosome]
GO:0010388 [cullin deneddylation]
GO:0016032 [viral process]
GO:0070062 [extracellular exosome]
GO:0070911 [global genome nucleotide-excision repair]
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 327 aa
36.2 kDa 		Yes 0
COPS6-004
ENSP00000400617
ENST00000418625
E7EM64 [Direct mapping]
COP9 signalosome complex subunit 6
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   Phobius predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
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 326 aa
36.1 kDa 		Yes 0
COPS6-007
ENSP00000388865
ENST00000419210
C9JQK5 [Direct mapping]
COP9 signalosome complex subunit 6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 42 aa
4.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.