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PAFAH1B2

GENERAL INFORMATION

Gene name

 PAFAH1B2

Gene description

 Platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues at variable levels.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA051836
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable), lung cancer (unfavourable), ovarian cancer (favourable) and liver cancer (unfavourable).
Pancreatic cancer p<0.001
Lung cancer p<0.001
Ovarian cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051836

GENE INFORMATION

Gene name

 PAFAH1B2

Synonyms

Description

 Platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) (HGNC Symbol)

Entrez gene summary

 Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2014]

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 117144267 - 117176894

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168092 (version 83.38)

Entrez gene

 5049

UniProt

 P68402 (UniProt - Evidence at protein level)

neXtProt

 NX_P68402

Antibodypedia

 PAFAH1B2 antibodies

PROTEIN BROWSER
PAFAH1B2-001
PAFAH1B2-004
PAFAH1B2-006
PAFAH1B2-007
PAFAH1B2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAFAH1B2-001
ENSP00000435289
ENST00000527958
P68402 [Direct mapping]
Platelet-activating factor acetylhydrolase IB subunit beta
V9HW44 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 303; Platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa, isoform CRA_a
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003847 [1-alkyl-2-acetylglycerophosphocholine esterase activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0007283 [spermatogenesis]
GO:0007420 [brain development]
GO:0016042 [lipid catabolic process]
GO:0016239 [positive regulation of macroautophagy]
GO:0042803 [protein homodimerization activity]
GO:0046982 [protein heterodimerization activity]
GO:0047179 [platelet-activating factor acetyltransferase activity]
GO:0070062 [extracellular exosome]
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 229 aa
25.6 kDa 		No 0
PAFAH1B2-004
ENSP00000431365
ENST00000530272
P68402 [Direct mapping]
Platelet-activating factor acetylhydrolase IB subunit beta
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003847 [1-alkyl-2-acetylglycerophosphocholine esterase activity]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0007420 [brain development]
GO:0016042 [lipid catabolic process]
GO:0016239 [positive regulation of macroautophagy]
GO:0047179 [platelet-activating factor acetyltransferase activity]
GO:0070062 [extracellular exosome]
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 202 aa
22.7 kDa 		No 0
PAFAH1B2-006
ENSP00000434951
ENST00000529887
P68402 [Direct mapping]
Platelet-activating factor acetylhydrolase IB subunit beta
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003847 [1-alkyl-2-acetylglycerophosphocholine esterase activity]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0007420 [brain development]
GO:0016042 [lipid catabolic process]
GO:0016239 [positive regulation of macroautophagy]
GO:0047179 [platelet-activating factor acetyltransferase activity]
GO:0070062 [extracellular exosome]
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 155 aa
17.8 kDa 		No 0
PAFAH1B2-007
ENSP00000304006
ENST00000304808
J3KNE3 [Direct mapping]
Platelet-activating factor acetylhydrolase IB subunit beta
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007420 [brain development]
GO:0047179 [platelet-activating factor acetyltransferase activity]
Show all
 175 aa
18.4 kDa 		No 0
PAFAH1B2-201
ENSP00000388742
ENST00000419197
P68402 [Direct mapping]
Platelet-activating factor acetylhydrolase IB subunit beta
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003847 [1-alkyl-2-acetylglycerophosphocholine esterase activity]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0007420 [brain development]
GO:0016042 [lipid catabolic process]
GO:0016239 [positive regulation of macroautophagy]
GO:0047179 [platelet-activating factor acetyltransferase activity]
GO:0070062 [extracellular exosome]
Show all
 132 aa
14.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.