Tissue expression of PAFAH1B2 - Summary - The Human Protein Atlas

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PAFAH1B2

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PAFAH1B2
Gene description	Platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues at variable levels.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA051836
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PAFAH1B2
Synonyms
Description	Platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) (HGNC Symbol)
Entrez gene summary	Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2014]
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	117144267 - 117176894
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168092 (version 83.38)
Entrez gene	5049
UniProt	P68402 (UniProt - Evidence at protein level)
neXtProt	NX_P68402
Antibodypedia	PAFAH1B2 antibodies

PROTEIN BROWSER

PAFAH1B2-001	PAFAH1B2-004	PAFAH1B2-006	PAFAH1B2-007	PAFAH1B2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PAFAH1B2-001 ENSP00000435289 ENST00000527958	P68402 [Direct mapping] Platelet-activating factor acetylhydrolase IB subunit beta V9HW44 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 303; Platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003847 [1-alkyl-2-acetylglycerophosphocholine esterase activity] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006629 [lipid metabolic process] GO:0007283 [spermatogenesis] GO:0007420 [brain development] GO:0016042 [lipid catabolic process] GO:0016239 [positive regulation of macroautophagy] GO:0042803 [protein homodimerization activity] GO:0046982 [protein heterodimerization activity] GO:0047179 [platelet-activating factor acetyltransferase activity] GO:0070062 [extracellular exosome] Show all	229 aa 25.6 kDa	No	0
PAFAH1B2-004 ENSP00000431365 ENST00000530272	P68402 [Direct mapping] Platelet-activating factor acetylhydrolase IB subunit beta Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003847 [1-alkyl-2-acetylglycerophosphocholine esterase activity] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006629 [lipid metabolic process] GO:0007420 [brain development] GO:0016042 [lipid catabolic process] GO:0016239 [positive regulation of macroautophagy] GO:0047179 [platelet-activating factor acetyltransferase activity] GO:0070062 [extracellular exosome] Show all	202 aa 22.7 kDa	No	0
PAFAH1B2-006 ENSP00000434951 ENST00000529887	P68402 [Direct mapping] Platelet-activating factor acetylhydrolase IB subunit beta Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003847 [1-alkyl-2-acetylglycerophosphocholine esterase activity] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006629 [lipid metabolic process] GO:0007420 [brain development] GO:0016042 [lipid catabolic process] GO:0016239 [positive regulation of macroautophagy] GO:0047179 [platelet-activating factor acetyltransferase activity] GO:0070062 [extracellular exosome] Show all	155 aa 17.8 kDa	No	0
PAFAH1B2-007 ENSP00000304006 ENST00000304808	J3KNE3 [Direct mapping] Platelet-activating factor acetylhydrolase IB subunit beta Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007420 [brain development] GO:0047179 [platelet-activating factor acetyltransferase activity] Show all	175 aa 18.4 kDa	No	0
PAFAH1B2-201 ENSP00000388742 ENST00000419197	P68402 [Direct mapping] Platelet-activating factor acetylhydrolase IB subunit beta Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003847 [1-alkyl-2-acetylglycerophosphocholine esterase activity] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006629 [lipid metabolic process] GO:0007420 [brain development] GO:0016042 [lipid catabolic process] GO:0016239 [positive regulation of macroautophagy] GO:0047179 [platelet-activating factor acetyltransferase activity] GO:0070062 [extracellular exosome] Show all	132 aa 14.9 kDa	No	0

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